Pharmacia : An Int. J of Pharm. Sc….2016, 2(3):120-130 Page 120 Available Online at www.ipsgwalior.org ISSN No. 2229-4309(Online), Vol - 2, Issue - 3, July 2016 Pharmacia: An International Journal of Pharmaceutical Sciences RESEARCH ARTICLE FORMULATION DEVELOPMENT AND EVALUATION OF MICROEMULSION GEL OF KETOCONAZOLE AS AN ANTIFUNGAL AGENT Heeramani Urmaliya* 1 , M. K. Gupta 2 , Ankit Agrawal 3 , Neetesh Kumar Jain 4 , Ankita Dubey 5 * 1,2,3,4,5 Oriental College of Pharmacy & Research, Oriental University, Indore -India ABSTRACT The aim of this investigation was to design and develop Microemulsion based gel (MBG) formulation of Ketoconazole for enhancing its solubility & permeability. Topical Permeability of Ketoconazole is very low. For this purpose, initially, solubility & permeability of Ketoconazole was determined in various vehicles. MBG was prepared with Capmul MCM NF as oil, Acrysol K150 as surfactant and Propylene Glycol as co-surfactant after preliminary screening of excipients. Carbopol 971 as gelling agent. The system was optimized by ternary phase diagram. The prepared formulations were characterized for Drug content, % Transmittance, Visual assessment, Particle size, Zeta potential and Compare In- vitro diffusion study of prepared MBG with Marketed formulation, Skin irritation study. The optimized batch contains mean particle size of 28.57nm and zeta potential (ζ) -8.25mV and viscosity study and Spreadability also in vitro diffusion/permeation study. In vitro diffusion study of optimized (MBG) formulation (F3) carried out which gives 78.95% within minute. And marketed formulation gives within 40minutes.Hence, by formulating into MBG, the solubility of Ketoconazole was found to be significantly enhanced. Keywords: ketoconazole, antifungal, solubility; particle size, viscosity. * 1 Corresponding author: Mr. Heeramani Urmaliya PG Research Scholar Department of Pharmacy Oriental University, Indore Email: heeramaniurmaliya@gmail.com