International Journal of Health Sciences and Research Vol.12; Issue: 11; November 2022 Website: www.ijhsr.org Original Research Article ISSN: 2249-9571 International Journal of Health Sciences and Research (www.ijhsr.org) 157 Vol.12; Issue: 11; November 2022 2-Chloroprocaine Versus Bupivacaine in Spinal Anaesthesia: A Randomized Controlled Study Priya Thappa 1 , Anju Jamwal 2 , Ashwani Kumar 3 , Kirtan Rana 4 1 Senior Resident, Department of Anesthesia, Postgraduate Institute of Medical Education and Research, Chandigarh, India 2 Professor, Department of Anesthesia and Intensive Care, Government Medical College, Jammu, India 3 Professor, Department of Anesthesia and Intensive Care, Government Medical College, Jammu, India 4 Assistant Professor, Department of Community Medicine, Government Medical College and Hospital, Chandigarh, India Corresponding Author: Anju Jamwal DOI: https://doi.org/10.52403/ijhsr.20221120 ABSTRACT Introduction: To cope with the increasing day care surgeries, a fast-acting, predictable anesthesia and time-efficient discharge is becoming the need of anesthesiologists. Spinal anesthesia has become popular nowadays in the day care settings due to the advent of new pencil point spinal needles. The study aims to compare 1% 2-Chloroprocaine with 0.5% Bupivacaine in spinal anesthesia with respect to the recovery from anesthesia and time taken to attain discharge readiness criterion. Methods: Around 100 patients belonging to ASA I and ASA II categories between the age group 18- 60 years undergoing surgery with an expected duration of < 60 minutes were selected. Using double- blinded randomization technique, the participants were equally divided into two groups and were given either 1% 2-Chloroprocaine or 0.5% Bupivacaine. The time taken for onset and regression of sensory as well as motor block was noted. Results: The achievement of the target sensory block was faster with 2-Chloroprocaine (137.20 ± 23.21 mins) than with 0.5% Bupivacaine (270.00 ± 34.10). The mean time to achieve unassisted ambulation in the 2-Chloroprocaine group (179.72 ± 17.30 mins) was less than the Bupivacaine group (256.52 ± 21.98 mins). The discharge readiness criteria were also attained earlier in the 2-CP group (195.98 ± 15.69 mins) than the Bupivacaine group (304.74 ± 16.99 mins). The incidence of postoperative Nausea and Vomiting was seen in 2% of the patients in both groups. Conclusion: 2-Chlorprocaine is a faster acting drug when compared to Bupivacaine and it helps in faster recovery of the patients undergoing daycare surgeries. Keywords: [2-Chloroprocainae, Bupivacaine, day care surgeries, recovery, spinal anesthesia.] INTRODUCTION Ambulatory surgery or Daycare surgery is defined as “The practice of admitting, on the day of surgery, of carefully selected and prepared patients for a planned, non- emergency surgical procedure and their discharge within 24 hours of that surgery”. 1 The increase in ambulatory surgical procedures has driven anesthesiologists to provide predictable anesthesia and time- efficient discharge of patients. 2 This has been made possible due to recent advances in anesthetic and surgical practices. Daycare anesthesia can several advantages for patients like a shortened hospital stay, minimum psychological disturbances, cost reduction, less risk of nosocomial infections and venous thromboembolism. The safety of anesthesia for daycare surgeries has increased due to the development of anesthesia, in terms of improved technology, the discovery of