Source of Funding: None MP76-15 EFFECT OF SILODOSIN ON PREMATURE EJACULATION Yoshikazu Sato*, Sapporo, Japan; Toshikazu Otani, Nagoya, Japan; Toshiyasu Amano, Nagano, Japan; Tohru Araki, Kurashiki, Japan INTRODUCTION AND OBJECTIVES: We have evaluated silodosin as a new treatment option for premature ejaculation (PE). Silodosin, a highly selective a1A-adrenoceptor antagonist, demon- strates excellent clinical efficacy for LUTS and has a strong sup- pressive action on ejaculation. This suppressive action is able to be applicable to treatment for PE. Our previous study demonstrated favorable effects on alleviation of PE symptoms (Sato et al. Int J Urol 2012). In this study, We compared efficacy of silodosin and naftopidil that has the weakest suppressive actions among a1 blockers as a control drug on PE. METHODS: Twenty seven patients who suffered with PE were enrolled in this study. PE was defined as IELT is about 3 mi- nutes or less and patients felt the inability to delay ejaculation and negative personal consequences due to the ISSM recommendation in 2014. Subjects had a mean age of 50.6years, reported having had PE for an average of 6.0 years. Eleven patients (41%) suffered with ED and had received treatment by phosphodiesterase type 5 in- hibitors before starting treatment for PE. Patients administrated silodosin 4 mg or naftopidil 25 mg 1 hours before intercourse in turn at least 3 times each. Intravaginal ejaculatory latency time (IELT), premature ejaculation profile item, clinical global impression change in PE, and systemic adverse events were evaluated. IELT measured using a watch by the patient. RESULTS: 1) Mean IELTs were 1.9, 4.1 and 7.6 minutes at baseline and with control and with silodosin, respectively. Silodosin significantly prolonged IELT compared to that at baseline and with control drug (p<0.01 table1). 2) Efficacy: Ten patients (37%) reported improvement for own PE problems under silodosin administration compared to baseline condition by the CGCI. Silodosin showed signif- icantly higher efficacy rate compared to that with control drug (p¼0.003). 3) Silodosin significantly improved ejaculation control and satisfaction of sexual intercourse compared to those at base line and with control (p <0.01). 4) Reduced semen volume and orgasm: Twelve patients (46%) experienced significant reduction of semen volume on silodosin administration. This rate was significantly higher than with control (p¼0.017). Six patients (23%) considered reduced semen vol- ume with silodosin as a significant problem. However, four patients achieved adequate IELT and normal ejaculation with satisfied orgasm by dose reduction (2mg-silodosn). 4) No systemic adverse effects were reported with silodosin. CONCLUSIONS: Silodosin significantly improved PE related problems than control drug. Reduced semen volume with silodosin was able to manage by dose reduction. Our current results confirmed the potential of silodosin as a new treatment option for PE. Source of Funding: none MP76-16 A PROSPECTIVE RANDOMIZED STUDY COMPARING THE EFFICACY AND SAFETY OF SILDENAFIL WITH DAPOXETINE IN TREATMENT OF PREMATURE EJACULATION Mohamed Elbakary*, Abd Elnaser Elgamasy, Sami Elmatit, Ahmed Essa, Tanta, Egypt INTRODUCTION AND OBJECTIVES: Premature ejaculation (PE) is one of the most common male sexual disorders and has been estimated to occur in 20% to 40% of men. Selective serotonin reuptake inhibitors (SSRIs) commonly used in treatment of PE. However, the use of sildenafil combined with dapoxetine to improve its efficacy is not yet fully investigated. We compared the efficacy and safety of sildenafil in combination with dapoxetine in treatment of premature ejaculation METHODS: 80 patients complaining of PE without erectile dysfunction (ED) divided into two groups by block randomization each group included 40 patients, the first was given on demand dapoxetine 30mg 1 to 3 hours before sexual intercourse, the second was given dapoxetine 30mg 1 to 3 hours combined with sildenafil 50mg 90 mi- nutes before sexual intercourse. Pre-treatment evaluation included self- administration of intra vaginal ejaculatory latency time (IELT) by stop- watch, self-administration of international index of erectile function (IIEF), grade of PE and sexual satisfaction scale (SSS). Patients were followed up at 1 and 3 months after treatment by IELT, grade of PE and SSS. RESULTS: Mean of IELT in group 1 was51.72  12.53, 289.0  23.29 and 322.0  24.62 seconds (P value <0.001) and in group 2 was 56.60  10.93, 298.75  17.86 and 352.50  29.33 seconds (P value <0.001) at baseline, 1 and 3 months after treatment respec- tively. Comparing the IIEF between the 2 groups there was statisti- cally significant improvement of IELT among patients in group 2 than those of group 1 at 1 month after medical treatment (P value ¼ 0.039) and after 3 months (P value <0.001). Baseline, 1 and 3 months after medical treatment the mean of SSS scores was 1.50  0.60, 2.80  0.65 and 3.48  0.55 in group 1 and 1.63  0.54, 3.25  0.67 and 4.10  0.50 in group 2 respectively. Statistical compar- ison showed significant improvement among group 2 patients at 1 (P value ¼ 0.004) and 3 months (P value <0.001) after treatment. Ac- cording to grade of PE the data was comparable and showed that there was significant reduction of grade of PE among patients of group 2 than those of group 1 after 1 (P value ¼ 0.001) and 3 months (P value ¼ 0.004) with mean values 5.0  0.82, 4.0  1.11 and 3.30  1.24 in group 1 and 4.80  0.72, 3.15  1.0 and 2.55  0.90 in group 2 at baseline, 1 and 3 months after treatment respectively. There was no statistically significant differences be- tween the 2 groups according to the side effects. CONCLUSIONS: combined ttt showed statistically significant improvement in IELT and grade of PE and SSS than dapoxetine alone but with more side effects but still tolerated Source of Funding: none MP76-17 PILATES FOR BETTER SEX: CHANGES IN SEXUAL FUNCTIONING IN HEALTHY TURKISH WOMEN AFTER PILATES EXERCISE Fikret Halis, Sakarya, Turkey; Pelin Yildirim, Kocaeli, Turkey; Ramazan Kocaaslan, Kursat Cecen, Kars, Turkey; Ahmet Gokce*, Sakarya, Turkey INTRODUCTION AND OBJECTIVES: Although a large number of studies report the impact of daily exercise on many aspects of women 0 s health, none of them address the relationship between Pilates exercise and sexual function prospectively. The aim of this study was to assess the effect of Pilates exercise on sexual function in healthy young women using a validated questionnaire. METHODS: Of 73 subjects, 8 who failed to meet the inclusion criteria and 31 who were eligible but declined to participate were Vol. 195, No. 4S, Supplement, Monday, May 9, 2016 THE JOURNAL OF UROLOGY â e1013