Global Journal of Cancer Case Reports | August 2019 | Volume 01| Issue 01 | Page 1-6 Arif M., MDA as A Bio-Marker for Benign Prostatic Hyperplasia in Pakistani Population Glob J Cancer Case Rep DOI: http://dx.doi.org/10.47733/GJCCR.2020.1107 http://www.cancercasereports.com/ 1 MDA as A Bio-Marker for Benign Prostatic Hyperplasia in Pakistani Population Maria Arif* 1 , Taha Arif 2 , Aadil Omer 3 , Owais Ahmed 4 *Corresponding author: Maria Arif Address: 1 National University of Sciences and Technology, Islamabad, Pakistan; 2 Ghurki Trust Teaching Hospital, Lahore, Pakistan; 3 Rawalpindi Institute of Cardialogy, Rawalpindi, Pakistan; 4 Gamga Ram Hospital, Lahore, Pakistan E-mail  Maria.aadil@yahoo.com Tel: +92-332-4549181 Received: 13 August 2019; Accepted: 20 August 2019 ABSTRACT Background: Serum malondialdehyde (MDA) is a convenient in vivo index of lipid peroxidation. It is a non-invasive biomarker of oxidative stress. Reactive oxygen species (ROS) could activate some specific signaling pathways that contribute to tumor development by regulating cell proliferation, angiogenesis and metastasis processes. Current study was designed to determine MDA levels in Benign Prostatic Hyperplasia (BPH) as compared to normal control. The study was a Cross-sectional analytical study, which was conducted at Department of Urology, Department of Biochemistry & Molecular Biology Rawalpindi, National University of Science and Technology, Islamabad over a period of one year. Study included sixty eight samples. MDA levels were determined by ELISA (enzyme linked immuno sorbent assay) technique. Results: We have compared mean value of MDA in BPH and control group, the difference was statistically significant (p=0.002). Conclusions: MDA may be used as bio-marker to determine progression of BPH. Moreover, it is required that additional studies should be carried out to find the pathway involved serum MDA in BPH. Key Words: Benign prostatic hyperplasia (BPH); Malondialdehyde (MDA); Gleason scoring Introduction and Review of Literature Prostate cancer is an early onset disease (Dvoracek, 1998). According to a study, oxidant- antioxidant imbalance may be one of the major factor responsible for the development of prostate cancer and benign prostate hyperplasia (Srivastava and Mittal, 2005). One of the source of prostate cancer is heterogeneous, possibly involving both genetic and environmental factor (Zhang et al., 2011). Research Article