Accepted Manuscript Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival Esra Yalcin, Mustafa C. Beker, Seyma Turkseven, Berrak Caglayan, Busra Gurel, Ulkan Kilic, Ahmet B. Caglayan, Rabia Kalkan, Ahmet T. Baykal, Taha Kelestemur, Ertugrul Kilic PII: S0041-008X(19)30294-7 DOI: https://doi.org/10.1016/j.taap.2019.114686 Article Number: 114686 Reference: YTAAP 114686 To appear in: Toxicology and Applied Pharmacology Received date: 21 March 2019 Revised date: 14 June 2019 Accepted date: 16 July 2019 Please cite this article as: E. Yalcin, M.C. Beker, S. Turkseven, et al., Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival, Toxicology and Applied Pharmacology, https://doi.org/10.1016/j.taap.2019.114686 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.