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DOI: 10.5897/ A
Artic le Numb e
S SN 1996-0808
Co p yri g ht © 20
Autho r (s ) re ta i n
http://www.a c
ull Length
β-Lact
choice
Acinetobac
critically ill
seven path
due to the
emergence
Acinetobac
modified K
according
Acinetobac
of A. johns
baumanni a
isolates of
ampicillin-s
of A. lwoffii
johnsonii a
A. baumann
sulbactam.
Acinetobac
having sulb
sulbactam,
species.
Key words:
TRODUCTION
netobacter is
omorphic, no
alase-positive
thogen. This
Corresponding a
uthor(s) agree
0International L
8-82, 14 Janua
AJMR2014.6840
r: 99518C8501
8
015
n the c o p yri gh
c ademic j o urn
Research
tam - β
e thera
Farhan R
Micro
cter, an imp
patients wh
ogens that d
organism’s
of multidru
cter spp. we
Kirby Bauer
to CLSI 201
cter johnsoni
sonii and all
and A. johns
A. baumann
sulbactam. F
i were susce
nd no isolat
nii, one isola
Cefoperazo
cter. Ninety
bactam were
though not
Acinetobacte
N
a Gram nega
on-fermenting
e and oxid
genus consis
author. E-mail:
that this articl
License
a ry, 2015
0
23
ht o f this a rtic l e
a ls.o r g / AJMR
h Paper
β-lactam
apy for
Rasheed*, R
obiology Depa
Rece
portant noso
hich results
disturb the h
capability to
ug resistant
ere evaluate
disc diffusio
12 guideline
ii and 6 were
l 6 isolates
sonii, and no
ni, one isola
Forty one (41
eptible to pip
e of A. lwoff
ate of A. joh
one-sulbacta
one percen
more effect
an antimicr
er, β-lactam –
ative cocco-b
, non-fastidio
dase-negative
sts of 35 spe
dr.farhanrashe
e remain perm
e
mase i
r multi
Raja Kamr
artment, Com
eived 19 April, 20
ocomial path
into high m
health care
o acquire di
and pan-dr
ed against f
on method u
es. Out of 1
e Acinetobac
of A. lwoffii
o isolate of A
ate of A. joh
1) isolates of
peracillin-su
fii were susc
nsonii, and n
am was the
t isolates w
tive as comp
robial, but do
– β-lactamase
bacillus, aerob
ous, non-mot
e opportunis
ecies (Turton
eed@gmail.co
manently open
Africa
inhibit
drug r
an Afzal an
mbined Military
014; Accepted 22
hogen, is c
morbidity and
delivery sys
iverse resist
rug resistant
five β-lactam
using Muelle
00 isolates,
cter lwoffii. E
i were multi
A. lwoffii wer
hnsonii and
f A. bauman
lbactam. Eig
ceptible to pi
no isolate of
most effec
were resistan
pared to othe
oes possess
e inhibitor com
bic,
ile,
stic
et
al., 2
respo
et al.
immu
m.
access under
an Journa
tor com
resista
nd Muham
y Hospital, La
2 December, 201
capable of c
d mortality w
stem. The sit
tance mecha
t strains. A
m – β-lactam
er-Hinton ag
85 were A
ighty four is
drug resista
re susceptib
no isolate o
nni, one isola
ght isolates o
iperacillin-ta
f A. lwoffii we
ctive combi
nt to pipera
ers. This wor
s antibacteri
mbinations, ce
2005). Out o
onsible for ab
, 2008). Acin
unocompromi
the terms of t
al of Micro
mbinat
ant Aci
mmad Jan L
ahore, Pakista
14
causing infe
worldwide. It
tuation has
anisms. This
total of 100
mase inhibit
gar. Zone si
Acinetobacter
olates of A.
ant. One iso
ble to co-amo
of A. lwoffii
ate of A. john
of A. bauma
azobactam. F
ere suscepti
nation agai
acillin-tazoba
rk also supp
ial activity a
efoperazone-
of these, Ac
bout 80% of c
netobacter ha
sed individua
the Creative C
obiology R
tions a
netoba
Leghari
an.
ectious outb
t is rated am
become com
s has resulte
0 clinical is
tor combina
zes were in
r baumannii
baumannii, 8
olate from ea
oxiclav. Twe
were susce
nsonii and n
anni, one iso
Forty eight is
ble to cefop
nst 49% iso
actam. Com
port the postu
against Acine
-sulbactam.
cinetobacter
clinical condit
as a high inci
als, particular
Commons Attri
Research
as the
acter
breaks in
mong top
mplicated
ed in the
olates of
ations by
terpreted
i, 9 were
8 isolates
ach of A.
enty eight
eptible to
no isolate
late of A.
solates of
perazone-
olates of
binations
ulate that
etobacter
baumannii i
tions (Sebeny
dence among
rly those who
bution License
s
y
g
o
e