Original research article EJO European Journal of Ophthalmology Quantitative measurements with optical coherence tomography angiography in Behc¸et uveitis Hilal Eser-Ozturk , Leman Ismayilova, Ozlem Eski Yucel and Yuksel Sullu Abstract Purpose: The aim of this study was to evaluate the quantitative measurements obtained by optical coherence tomog- raphy angiography in patients with Behc¸et uveitis. Methods: A total of 22 consecutive patients with Behc ¸et uveitis and 19 age-matched healthy individuals were included in the study. Quantitative analysis of optical coherence tomography angiography images was performed. Comparisons between the patients and the control groups and correlation analysis between optical coherence tomography angiog- raphy results and age, visual acuity, duration of uveitis, central macular thickness, and fluorescein angiography scores in the patient group was performed. Results: The mean superficial foveal avascular zone area was 283.040 Æ 113.003 mm 2 in the patient group and 254.268 Æ 75.813 mm 2 in the control group (p ¼ 0.821). The mean deep foveal avascular zone area was 317.657 Æ 116.225 mm 2 in the patient group and 332.954 Æ 94.783 mm 2 in the control group (p ¼ 0.775). The foveal avascular zone area could not be calculated in eight eyes with macular atrophy in the patient group because of unclear foveal avascular zone borders. Both superficial and deep capillary vessel density in all regions were lower in the patient group than in the control. Superior, inferior, and temporal capillary vessel density were correlated with fluorescein angiography score (Pearson’s r ¼ –0.380, 0.392, and –0.384, p < 0.05 in superficial plexus; r ¼ –0.357, –0.401, and –0.321, p < 0.05 in deep plexus, respectively). The foveal avascular zone area was correlated with central macular thickness in both superficial and deep plexus (r ¼ –0.387 and –0.331, p < 0.05, respectively). Conclusion: Recurrent uveitis attacks affecting the macula are associated with a decrease in capillary vessel density and expansion in the foveal avascular zone area in Behc¸et disease. The qualitative evaluation of the optical coherence tomography angiography findings may be more valuable in patients with macular atrophy. Keywords Behc¸et uveitis, capillary vessel density, foveal avascular zone, optical coherence tomography angiography, swept-source optical coherence tomography angiography Date received: 8 November 2019; accepted: 27 March 2020 Introduction Behc¸et uveitis is characterized by non-granulomatous panuveitis and retinal vasculitis. Although the disease may affect all types of retinal vasculature, retinal veins are mostly involved in the form of leaky periphlebitis and/or venous occlusion. Fluorescein angiography (FA) may show retinal vascular leakage, retinal ische- mia, and neovascularization of the disc or elsewhere. In addition, persistent leakage seen in FA is an indication of insufficient control of the disease in patients without Department of Ophthalmology, Ondokuz Mayis University, Samsun, Turkey Corresponding author: Hilal Eser-Ozturk, Ondokuz Mayıs € Universitesi, G€ oz Hastalıkları A.D., Kurupelit, 55139 Samsun, Turkey. Email: hilaleser@yahoo.com European Journal of Ophthalmology 0(0) 1–9 ! The Author(s) 2020 Article reuse guidelines: sagepub.com/journals-permissions DOI: 10.1177/1120672120920214 journals.sagepub.com/home/