Health, 2014, 6, 2261-2285 Published Online September 2014 in SciRes. http://www.scirp.org/journal/health http://dx.doi.org/10.4236/health.2014.616262 How to cite this paper: Blum, K., et al. (2014) Hypothesizing “Reward” Gene Polymorphisms May Predict High Rates of In- jury and Addiction in the Workforce: A Nutrient and Electrotherapeutic Based Solution. Health, 6, 2261-2285. http://dx.doi.org/10.4236/health.2014.616262 Hypothesizing “Reward” Gene Polymorphisms May Predict High Rates of Injury and Addiction in the Workforce: A Nutrient and Electrotherapeutic Based Solution Kenneth Blum 1-7* , Thomas Simpaatico 3 , Roger L. Waite 2 , Seth H. Blum 2 , Kristina Dushaj 3 , Margaret A. Madigan 2,6 , Eric R. Braverman 1,3 , Marlene Oscar-Bermanm 8 1 Department of Psychiatry and McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, USA 2 Department of Nutrigenomic Research, RDSolutions, LLC, Del Mar, USA 3 Department of Neurology, PATH Foundation NY, New York, USA 4 Dominion Diagnostics, LLC, North Kingstown, USA 5 Department of Psychiatry, Human Integrated Services Unit University of Vermont Center for Clinical & Translational Science, College of Medicine, Burlington, USA 6 Department of Genomics, IGENE, LLC, Austin, USA 7 Department of Addiction Research & Therapy, Malibu Beach Recovery Center, Malibu Beach, USA 8 Departments of Psychiatry, Neurology, and Anatomy & Neurobiology, Boston University School of Medicine, and Boston VA Healthcare System, Boston, USA Email: * –drd2gene@gmail.com Received 14 July 2014; revised 31 August 2014; accepted 1 September 2014 Copyright © 2014 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/ Abstract We hypothesize that individuals with genetic predisposition to Substance Use Disorder (SUD) may have greater likelihood of experiencing work related accidents. We further hypothesize that high risk populations will carry single or multiple polymorphisms associated with brain reward circui- try and/or brain reward cascade, including: Dopaminergic (i.e. DRD2 receptor genes); Serotoner- gic (i.e. 5-HTT2 receptor genes); Endorphinergic (i.e. pre-enkephalin genes); Gabergic (i.e. GABA A receptor genes); Neurotransmitter Metabolizing genes (i.e. MAO and COMT genes) among others (GARS RX™ ). Analgesic addiction as well as “pseudoaddiction” must be treated to improve pain con- trol and its management. We propose that non-pharmacological alternatives to pain relief, in high * Corresponding author.