Vol.:(0123456789) 1 3 Eur Arch Otorhinolaryngol DOI 10.1007/s00405-017-4546-3 RHINOLOGY The efects of septoplasty surgery on serum oxidative stress levels Adnan Ekinci 1  · Duran Karataş 1  · Abdurrahman Yetiş 1  · Emre Demir 2  · Muge Ozcan 1   Received: 2 December 2016 / Accepted: 20 March 2017 © Springer-Verlag Berlin Heidelberg 2017 deviation (NSD) is a frequent cause of nasal obstruction, and it is defned as displacement of the nasal septum towards one side [2]. Hypoxia due to nasal obstruction is not uncommon [3]. It has been claimed that some cellular compartments may be lost, and increased amounts of free oxygen radicals are released from lysosomes [4]. Stud- ies have reported that production of free oxygen radicals increases as a result of the hypoxia/reoxygenation periods [5]. Septoplasty is the main surgical procedure to overcome nasal obstruction caused by septal deviation [6–8]. To our knowledge, no studies in the English literature investigated total antioxidant status (TAS), total oxidant status (TOS), and paraoxonase (PON1) levels in patients with NSD before and after septoplasty. Ours is the frst study in the literature in which the paroxonase enzyme levels, as a new measurement method of oxidative stress, have been inves- tigated in association with TAS and TOS in patients who have undergone septoplasty. Materials and methods This study was conducted in Hitit University, Faculty of Medicine, Otolaryngology Clinic between January 01 and October 07, 2016. The study protocol was approved by Gaziosmanpaşa University, Ethics Committee for Clinical Research (Decree No.: 15-KAEK-192). Forty- six individuals between the ages of 18 and 50 years who were diagnosed with NSD were included in the study. The diagnosis of NSD was made with anterior rhinos- copy and nasal endoscopic examination performed in patients who were presented to our clinic with the com- plaint of nasal obstruction. The individuals with athero- sclerotic heart disease, malignancy, hypertension, severe Abstract The aim of this study is to compare the total antioxidant status (TAS), total oxidant status (TOS), and paraoxonase (PON1) serum levels in patients who have undergone septoplasty (NSD). Forty-six patients (mean age 33.7) aged between 18 and 50 years who were diagnosed with nasal septal deviation (NSD) were included in the study. The TAS, TOS, and PON1 levels were compared in the serum samples obtained 1 month before the septoplasty and 3 months after surgery. There was a signifcant increase in mean TAS after septoplasty (1.041 vs. 1.124 mmol/L, p = 0.011). The mean TOS decreased signifcantly after septoplasty (20.631 vs. 5.946 mmol/L, p = 0.011). The mean pre- and postoperative PON1 levels were similar (326.93 ± 215.22 vs. 275.20 ± 167.76 U/L, p = 0.253). Increased TAS and decreased TOS after septoplasty show that patients with NSD are under oxidative stress that is relieved following septoplasty. Keywords Septoplasty · Total oxidant status · Total antioxidant status · Paraoxonase Introduction Nasal obstruction is a very frequently encountered com- plaint in otolaryngology practice [1]. Nasal septum * Adnan Ekinci draekinci@hotmail.com 1 Department of Otorhinolaryngology Head and Neck Surgery, Hitit University, üctutlar mah.ahcılar 16.sokak. Ada apt.10/15, 19000 Corum, Turkey 2 Department of Biostatistics, Faculty of Medicine, Hitit University, Corum, Turkey