Vol 14, Issue 3, 2021 Online - 2455-3891 Print - 0974-2441 IDENTIFICATION AND ANALYSIS OF DRUG-RELATED PROBLEMS INCIDENCE AT HOSPITALIZED PATIENTS IN HAJI REGIONAL GENERAL HOSPITAL, MAKASSAR MUHAMMAD ALDILA SATRIA 1 *, SUDIBYO SUPARDI 2 1 Department of Pharmaceutical Science, Faculty of Pharmacy, University of Indonesia, Depok, West Java, Indonesia, 2 Department of Health Resources, National Institute of Health Research and Development, Indonesian Ministry of Health, Jakarta, Indonesia. Email: muhammadaldilasatria@gmail.com Received: 27 November 2020, Revised and Accepted: 19 January 2021 ABSTRACT Objective: This study aims to identify inpatient medication problems and analyze the association between patient characteristics and the incidence of the drug-related problem (DRP) experienced by patients. Methods: The cross-sectional study was conducted at Haji Regional General Hospital, Makassar, using medical record data for inpatients from January to February 2020. Data were collected from September to October 2020. A total of 247 inpatients were identified using the Indonesian version of the Pharmaceutical Care Network Europe. Results: The most common DRP problem found is the effect of drug treatment not optimal (P1.2) by 35.76% and the most common cause found is no or incomplete drug treatment despite existing indication (C1.6) by 20.16%. Bivariate analysis shows that age, length of stay, and the number of drugs received are significant different with the incidence of DRP in patients (p < 0,01) respectively. Multivariate analysis using logistic regression shows that age, sex, and the number of drugs could significantly affect the incidence of DRP (p<0.05) with the r-square (R 2 ) of 21.6%. According to this model, the largest odds ratio number and the most likely to experience DRP in a patient are age, the number of drugs, then gender (5,2; 4,6; and 2,3). Conclusion: Age, length of stay, and the number of drugs received affect the DRP incidence in a patient, while gender together with age and the number of drugs affecting the incidence of DRP in a patient. Keywords: Identification, Drug-related problem, Patient treatment. INTRODUCTION Drug-related problem (DRP) is events or circumstances involving actual or potential drug therapy that can interfere with desired health outcomes [1]. DRP is often found and occurs in many communities, whether self-medication or consulting doctors [2] in primary, secondary, and tertiary health services. DRP occurs when inappropriate prescribing, ineffective, or unnecessary medication, underdose, overdose, the presence of unwanted drug events, patient non-compliance, and so on [3]. Lack of knowledge and patient non- compliance with medication use can be a significant factor in increasing the risk of DRPs [4]. This study is supported by the results of a study conducted by Al-Azzam in 2016, showing that 82.1% of chronic disease patients need education and counseling [3]. Moreover, since disease patients follow a complex treatment regimen, it was also identified as a critical factor in the increased risk of DRP in patients [5,6]. In Indonesia, DRP can occur in several diseases, especially chronic diseases. Several studies conducted which identified DRP in patients with several chronic diseases such as kidney failure [7], diabetes mellitus [8], and heart failure [9] showed that the treatment carried out in the patient still has the potential for DRPs. The study results concluded that pharmacists’ role in identifying, solving, and reducing the incidence of DRP in patients is needed [9]. It is then under the standard of pharmaceutical services in the hospital, as stated in the Minister of Health Regulation No. 72 of 2016, which states that identifying DRP is part of monitoring drug therapy activities carried out by pharmacists in hospitals. Therefore, this study aims to identify the types of DRP in inpatients at the general hospital in Makassar, South Sulawesi. We also want to analyze the relationship between patient characteristics (age, gender, length of stay, and the number of drugs received) to the patients’ DRP incidence. METHODS This study used a cross-sectional design. The study was conducted at the Haji General Hospital, Makassar, South Sulawesi with a data collection period from September to October 2020. This study has been examined and approved by the Health Research Ethics Committee of the Faculty of Medicine, University of Indonesia number KET-516/UN2. F1/ETIK/PPM.00.02.2020 with the protocol number 20-05-0529. The research sample was inpatients, who visited the hospital during the period January–February 2020. Two hundred forty-seven patients were recruited in this study which fulfilled the requirements of the Slovin’s formula and complied with the inclusion criteria as follows, that is, had been hospitalized and age >18 years. Meanwhile, the patient exclusion criteria were the patient’s medical records, were not well documented. We check for data completeness and compliance with the study inclusion criteria. They were followed by analyzing and identifying the DRP experienced by the patients while being treated with variables used in this study, that is, gender, age, length of stay, as well as the number of drugs received as independent variables and the number of DRP experienced by patients as the dependent variable. It also identifies the types of DRP experienced by patients by filling in the instrument’s code on the DRP registration form using the Indonesian version of the Pharmaceutical Care Network Europe (PCNE). References such as Lexicomp, Medscape, IBM Micromedex, Pharmacotherapy Handbook, © 2021 The Authors. Published by Innovare Academic Sciences Pvt Ltd. This is an open access article under the CC BY license (http://creativecommons.org/ licenses/by/4.0/) DOI: http://dx.doi.org/10.22159/ajpcr.2021v14i3.40391. Journal homepage: https://innovareacademics.in/journals/index.php/ajpcr Research Article