P-23 AMBULATORY BLOOD PRESSURE OF ADULTS IN NOVOSIBIRSK, RUSSIA: INTERIM REPORT ON A POPULATION STUDY T. V. Kuznetsova, S. K. Malyutina, E. V. Pello, L. Thijs, Y. P. Nikitin, J. A. Staessen. 1 Institute of Internal Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia, 2 Hypertension Unit, University of Leuven, Belgium The aim of this study was to describe the distributions of the ambulatory blood pressure in a sample drawn from the Siberian population. In the European Project On Genes in Hypertension (EPOGH), a random population sample of 162 persons (72 men and 90 women) was investigated in Novosibirsk, Russia. Mean age (SD) was 40.6  15.3 years. Validated oscillometric 90207 SpaceLabs monitors were programmed to obtain am- bulatory blood pressure readings at intervals of 15 min from 8 AM to 10 PM and at 30 min intervals from 10 PM to 8 AM. Day-time and night-time were defined using short fixed-clock time intervals, which ranged from 10 AM to 8 PM and from midnight to 6 AM respectively. In the 162 participants, of whom 54 were hypertensive, 24-hour, clock-time day and clock-time night blood pressures averaged 120/73, 126/79 and 110/60 mm Hg, respectively. Compared with day-time val- ues, blood pressures at the clinic were 5.7/1.1 mm Hg lower in 108 normotensive people, but 17.0/13.1 mm Hg higher in 54 hypertensive patients. In the normotensive subgroup, the 95th percentiles of the 24-hour, clock-time day and clock-time night blood pressures were 128/81, 136/86 and 118/72 mm Hg, respectively. In comparison with other population surveys, the present interim report on the EPOGH study produced consistent results with respect to the distributions of the ambulatory measurements both in normotensive subjects and in the overall study population. Key Words: Ambulatory blood pressure, Population, Distribution P-24 DILTIAZEM 180 MG IN SLOW RELEASE CAPSULES. EVALUATION OF TROUGH:PEAK RATIO BY AMBULATORY BLOOD PRESSURE MONITORING C. Cotta, J. Calac ¸a, L. P. Martins, P. Calac ¸a, M. J. Palma, R. Duarte, M. A. Basto, R. Palma-Reis. 1 Corsintra, Lisboa, Portugal An antihypertensive drug taken once-a-day must cover the 24 hours with a trough:peak ratio greater than 50%. We evaluated the trough:peak ratio of slow release capsules of Dilti- azem 180 mg taken in a single dose in the morning (8-10 a.m.) in 23 patients with essential hypertension with systolic or diastolic tensional load  20%. Patients were submitted to a 24 hour Ambulatory Blood Pressure Monitoring (ABPM) after a double blind, crossover period of 4 weeks with Diltiazem 180 mg or placebo. Diltiazem 180 mg in slow release capsules significantly decreases Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Mean Blood Pressure (MBP) (24h mean, daytime - 08-23h - and night- time - 24-07h) (table). ABPM Results (MeanSD) Placebo Diltiazem Significance 24 h SBP (mm Hg) 148.6  7.0 142.3  6.4 p0.0001 24 h DBP (mm Hg) 93.8  8.1 87.9  6.4 p0.0001 24 h MBP (mm Hg) 121.2  7.3 115.1  6.3 p0.0001 Daytime SBP (mm Hg) 152.6  4.1 145.2  3.6 p0.0001 Daytime DBP (mm Hg) 98.5  5.5 91.4  4.2 p0.0001 Daytime MBP (mm Hg) 125.5  4.3 118.7  3.9 p0.0001 Night-time SBP (mm Hg) 140.7  4.2 135.2  4.0 p=0.001 Night-time DBP (mm Hg) 84.6  3.1 80.8  3.3 p=0.001 Night-time MBP (mm Hg) 112.7  3.6 108.0  3.4 p=0.001 The trough:peak ratio was calculated using the mean blood pressures at 8, 9 and 10 hours (trough) and at 18, 19, 20 hours (peak) for SBP, DBP and MBP. The comparison of the circadian curves of SBP between placebo and the therapeutic active period demonstrated that Diltiazem 180 mg in this formulation taken in the morning has a peak effect 10 to 13 hours after the dose and the anti-hypertensive effect is maintained for 22-24 hours. At night the curves get closer with no nocturnal hypoten- sion. The calculated trough:peak ratios were high (90.4% for SBP, 89.4% for DBP and 81.0% for MBP). We concluded that Diltiazem 180mg in slow release capsules taken once daily in the morning efficaciously decreases blood pressure during 24 hours and respects the circadian blood pressure variation with a high trough:peak ratio and without nocturnal hypotension. Key Words: Ambulatory BP Monitoring, Trough:peak, Diltiazem P-25 CLINICAL EVALUATION OF A WRIST BLOOD PRESSURE DEVICE WITH AN ACTIVE POSITIONING SYSTEM BY COMPARISON WITH 24-H AMBULATORY BLOOD PRESSURE MEASUREMENT S. Uen, B. Weisser, H. Vetter, T. Mengden. 1 Department of Internal Medicine, University Clinic, Bonn, Germany Wrist devices for self blood pressure measurement (self-BPM) are to be considered with caution due to the risk of errors when used inappropri- ately. The purpose of this study was to evaluate the clinical performance of a new wrist device with an active positioning system (Braun Preci- sionSensor) validated according to Association for the Advancement of Medical Intrumenation (AAMI) guidelines. 20 normo- and 23 hyperten- sive, untreated subjects (between 23 and 81 years) with no training in self-BPM and no experience with wrist devices performed self-BPM over 7 days according to the recent Consensus guidelines. A short written instruction for the measuring technique was provided but no further instruction by the investigator was given. ABPM was performed with a highly accurate device (A&D TM 2430) validated according to AAMI and British Hypertension Society protocol. 24-h-ambulatory-BPM (ABPM; 24-h mean: 13215/808 mmHg) was compared with stored data of mean self-BPM, casual screening-BPM by general physicians (GP) and multiple clinic-BPM by an experienced observer (clinic read- ings). Pearson correlation coefficient between self-BPM and 24-h ABPM was 0.73 for systolic (p0.0001) and 0.65 for diastolic values (p0.0001). Self-BPM correlated better with ABPM than casual screen- ing-BPM by GPs (r=0.59 for syst., 0.57 for diast. values). Correlation coefficients between ABPM and the multiple clinic readings were 0.69 for syst. and 0.65 for diast. values. False classification of normotension/ hypertension taking ABPM as the gold standard was 18% for wrist self-BPM (cut-off value: 135/85 mmHg) and 21% for multiple clinic readings (cut-off value: 140/90 mmHg). Self-BPM with the Braun PrecisionSensor performed by untrained subjects showed a comparable agreement with ABPM as recently ob- served for self-BPM with upper-arm devices. Classification of normo- tension/hypertension with the wrist device tended to be more reliable as with multiple clinical readings by a trained observer. Grant/Research Support - Braun Gmbh, Germany Key Words: Self blood pressure measurement, Validation, Ambulatory blood pressure P-26 SUBJECTS WITH HIGH-NORMAL BLOOD PRESSURE HAVE HIGHER AMBULATORY BLOOD PRESSURE VALUES AND DECREASED BAROREFLEX SENSITIVITY COMPARED TO NORMOTENSIVES Giovanna Franconi, Angela Ciamei, Antonietta De Luca, Deborah Berti, Ambrogio Capria. 1 Clinica Medica, Tor Vergata University, Roma, Italy Subjects with high-normal blood pressure (BP) (130-139 / 85-89 mm Hg) have increased cardiovascular risk. We tested the hypothesis that the BP 37A AJH–April 2001–VOL. 14, NO. 4, PART 2 POSTERS: Blood Pressure Measurement/Monitoring Downloaded from https://academic.oup.com/ajh/article/14/S1/37A/141235 by guest on 06 February 2023