Autonomic nervous system Clinical neurophysiology Critical care P 2121 Myocardial 123I-metaiodobenzylguanidine (MIBG) Scintigraphy for the assessment of cardiac sympathetic nervous dysfunction in diabetic patients J . Nunomura 1 , O. Uehara 2 , M. Baba 3 , M. Matsunaga 3 1 Department of Neurology, Municipal Kuroishi Hospital, Kuroishi, Aomori, JAPAN, 2 Department of Internal Medicine, Municipal Kuroishi Hospital, Kuroishi, Aomori, JAPAN, 3 Department of Neurology, Hirosaki University, Hirosaki, Aomori, JAPAN Purpose Although diabetic autonomic neuropathy constitutes serious complications, there are few methods for early detection of abnormalities. In this study, we conducted 123I-MIBG myo- cardial scintigraphy, which is currently applied as a test of cardiac sympathetic nerve function, on diabetic patients, and assessed its usefulness by comparing with the results of sympa- thetic skin response (SSR), which is a method for evaluating peripheral sympathetic nerve activity. Subjects We examined 29 cases of type 2 diabetes that did not present autonomic dysfunctions (11 males and 8 females). The average age of the subjects was 64.9 years and the mean dura- tion of diabetes was 13 years. Methods MIBG uptake was quantified by calculation of the heart - mediastinum ratio (H/M ratio) that was calculated by average count per pixel in the regions of interest over heart and mediastinum on the planar anterior image of the chest. In addi- tion, the washout rate (WR) was also calculated. SSR was per- formed followed by determination of amplitude and latency. Results According to the results of 123I-MIBG myocardial scintigraphy, abnormalities in H/M ratio and WR were observed in 10 cases. Decreased amplitude was observed in 9 cases in SSR. H/M ratio and WR did not correlate with symptoms of diabetic peripheral neuropathy, and there was no correlation observed with the results of SSR as well. Discussion 123I-MIBG myocardial scintigraphy, along with SSR, is a simple and objective evaluation method, and is con- sidered to be a useful method for assessing early diabetic auto- nomic neuropathy. P 2122 Sympathetic skin response and foot ulceration in diabetes P. Kokotis 1 , A. Karanti 3 , N. Tentolouris 2 , P. Tsapogas 2 , N. Katsilambros 2 , U. Smith 3 and C. Karidakis 1 1 Neurological Department of Laiko Hospital, Athens, GREECE, 2 1 st Department of Propaedeutic Medicine, Athens, University Medical School, Athens, GREECE, 3 Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, SWEDEN Background-Aims This study examined the relationship bet- ween sympathetic skin response (SSR) as a reliable test of auto- nomic nervous system function and foot ulceration (FU) in diabetes. Materials and Methods 64 patients with either type 1 or type 2 diabetes were studied. Diagnosis of peripheral sensory neuro- pathy (PN) was based on clinical symptoms, signs and vibra- tion perception threshold. DS were divided in 3 groups: without 6th EFNS Congress, Vienna, 2002 138 © 2002 EFNS European Journal of Neurology 9 (Suppl. 2), 105–161