_____________________________________________________________________________________________________ *Corresponding author: E-mail: bruno.chinko@uniport.edu.ng; Int. Blood Res. Rev., vol. 14, no. 3, pp. 10-18, 2023 International Blood Research & Reviews Volume 14, Issue 3, Page 10-18, 2023; Article no.IBRR.99270 ISSN: 2321–7219 Honey Attenuates Phenylhydrazine- Induced Hematotoxicity and Oxidative Stress in Male Wistar Rats Bruno C. Chinko a* , Dibo T. Pughikumo b , Onyebuchi Obia c , Winifred C. Udeh d and Victor O. Hart a a Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences. University of Port Harcourt, Port Harcourt, Nigeria. b Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria. c Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Amassoma, Nigeria. d Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences. University of Port Harcourt, Port Harcourt, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/IBRR/2023/v14i3308 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/99270 Received: 20/02/2023 Accepted: 24/04/2023 Published: 25/04/2023 ABSTRACT Honey is a sweet, viscous food substance produced by bees using nectar from flowers. Due to its complex chemical composition, it has been widely used in traditional medicine for its therapeutic properties. The present study evaluated the protective role of honey in attenuating phenylhydrazine (PHZ)-induced toxicity in male Wistar rats. Twenty (20) male Wistar rats with a weight range of 200-250g were used for the study. They were allocated into four (4) groups consisting of five (5) rats each. In the first phase of the experiment, animals in group I (control) received distilled water Original Research Article