_____________________________________________________________________________________________________ *Corresponding author: E-mail: wanjari605@gmail.com; Journal of Pharmaceutical Research International 33(47A): 850-853, 2021; Article no.JPRI.74600 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Case of 38 Years old Nulligravida with Primary Infertility with a Known Case of Diabetes Mellitus Came for in vitro Fertilization Deeplata Mendhe 1 , Maheshwari Bombale 2 and Mayur Wanjari 1* 1 Department of Community Health Nursing, Smt. Radhikabai Meghe Memorial College of Nursing, Datta Meghe Institute of Medical Sciences, Sawangi (M), Wardha, Maharashtra, India. 2 Smt. Radhikabai Meghe Memorial College of Nursing, Datta Meghe Institute of Medical Sciences, Sawangi (M) Wardha, Maharashtra, India. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i47A33081 Editor(s): (1) Dr. Giuseppe Murdaca, University of Genoa, Italy. Reviewers: (1) Thotakura Balaji, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, India. (2) Mohammad Abdel Qader M. Al-Ma’ani, UAE. Complete Peer review History: https://www.sdiarticle4.com/review-history/74600 Received 05 August 2021 Accepted 11 October 2021 Published 30 October 2021 ABSTRACT Introduction: The term “Primary infertility” refers to a couple’s inability to conceive a child. Endometriosis: affects mostly women in their 30s and 40s, with roughly 40%of women suffering from endometriosis. This occurs when the uterine lining is discovered outside of the uterus. Endometriosis will make it difficult to conceive. Not everyone aspires to be a parent, but for those who do, the inability to produce a child is a heart-breaking reality. Many of us spend a significant portion of our lives trying to avoid unintended pregnancies, assuming that when we are ready to have a family, it will have happened naturally. We tend to believe that transiting from preventing pregnancy to planning conception and childbirth will be relatively painless and orderly. As a result, the inability to conceive is a major life stressor that can wreak havoc on otherwise happy couples. Case Presentation: She is a case of 48 yr. Primary Infertility nulligravida comes with DM. For 20 Year diagnostic hysteroscopy done. Ultrasonography done. A complete blood investigation is done. She is a history of Hypertension for 1 month and insulin-dependent diabetes for one 1year. Conclusion: This study emphasized the opportunity of strengthening public health and hospital- Case Study