Contents lists available at ScienceDirect Food Chemistry journal homepage: www.elsevier.com/locate/foodchem Scientifc basis for the industrialization of traditionally used plants of the Rosaceae family P. Garcia-Oliveira a ,M.Fraga-Corral a,b ,A.G.Pereira a,b ,C.Lourenço-Lopes a ,C.Jimenez-Lopez a,b , M.A. Prieto a, ⁎ , J. Simal-Gandara a, ⁎ a Nutrition and Bromatology Group, Analytical and Food Chemistry Department, Faculty of Food Science and Technology, University of Vigo, Ourense Campus, E-32004 Ourense, Spain b Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolonia, 5300-253 Bragança, Portugal ARTICLEINFO Keywords: Traditionally used plants Ethnobotanic Rosaceae family Bioactive compounds ABSTRACT Plants have been traditionally used for the treatment of diferent types of illness, due to biomolecules with recognised benefts. Rosaceae family is used in traditional Galician medicine. The following plants Agrimonia eupatoria, Crataegus monogyna, Filipendula ulmaria, Geum urbanum, Potentilla erecta and Rosa canina are usually found in treatments. The aim of this study is to perform an ethnobotanical review about the bioactive com- pounds of these plants and their diferent bioactivities, both studied in vitro and in vivo. The nature of the bioactive compounds is varied, highlighting the presence of diferent phenolic compounds, such as phenolic acids, favonoids or tannins. Understanding the benefcial efects of the administration of the whole plant or targettissuesfrom A. eupatoria, C. monogyna, F. ulmaria, G. urbanum, P. erecta and R. canina aswellasthosefrom theirindividualcompoundscouldleadtothedevelopmentofnewdrugsbasedontheuseofnaturalingredients. 1. Oraltraditionandtheknowledgebasedontrialanderror 1.1. History of traditionally used Plants: Worldwide to Galicia (NW Spain) Sincetheancienttimes,peopleinstinctivelysoughttheremediesfor painanddiverseillnessinthesurroundingnature(Sengupta,Gaurav,& Tiwari, 2018; Srivastava, 2018). All knowledge was based on experi- ence,astherewasnoinformationaboutthereasonsforthediseaseor which plant and its form of consumption could be useful for its treat- ment. After thousands of years of trial and error throughout human history, specifc plants consumed via oral administration were identi- fed forthetreatmentofspecifcdiseases,thereforeknownasmedicinal plants (Srivastava, 2018). Plants may contain diverse chemical com- pounds, named active or bioactive compounds, such as alkaloids or essential oils (EO) (Pérez, 1998). The correct administration of these biomolecules may have benefcial efects on health. In fact, some of these bioactive compounds are the foundation of modern medicine drugsandtheyrepresentanalternativesourceofinnovativeingredients with further applications in food and cosmetic industries. Along the historyofthetraditionallyusedplants,at frst,informationwaspassed orally from generation to generation, until the start of writing. Nu- meroustextsdescribetheuseofdiferentplantsinancientcivilizations, suchastheSumerian,Egyptian,Indian,Chinese,Greek,RomanorArab (Sengupta et al., 2018; Srivastava, 2018). The Ebers Papyrus contains descriptions of diferent treatments, based on plants, to treat skin, ur- inary, ophthalmologic and other infections (Lennihan, 2014; Srivastava, 2018). Some of the treatments from the Ayurveda Indian medical system and Traditional Chinese medicine have similar basis and the species they described are still used today (Lennihan, 2014; Srivastava, 2018). Initially, plants were consumed raw, and later, people added them to hot water (W) to create soup and tea. As knowledge grew, diferent herbs were combined to elaborate more complextreatises(Lennihan,2014).AncientGreeksareconsideredthe parents of modern medicine, as they combined traditional practices with scientifc thinking. Hippocrates, Galen and Dioscorides, among otherauthors,showedtheirinterestinthedeeperapplicationofplants by writing vast treatises (Srivastava, 2018). In Corpus Hippocraticum, diferentherbalmedicinesandtheir formsoftreatmentweredescribed foreachdisease(Lennihan, 2014; Pahlow, 1994). Galen diferentiated between the use of plants “at natural” (meaning in powder form) and thegalenicpreparations:bioactivecompoundswereconcentratedinW, ethanol(Et)orvinegar,thenusedinointment,plastersorothergalenic forms (Pahlow, 1994). Dioscorides wrote De Materia Medica, with de- scriptions, modes of collection, preparation and therapeutic efects of https://doi.org/10.1016/j.foodchem.2020.127197 Received9February2020;Receivedinrevisedform16March2020;Accepted29May2020 ⁎ Corresponding authors. E-mail addresses: mprieto@uvigo.es (M.A. Prieto), jsimal@uvigo.es (J. Simal-Gandara). Food Chemistry 330 (2020) 127197 Available online 08 June 2020 0308-8146/ © 2020 Elsevier Ltd. All rights reserved. T