Open Peer Review Any reports and responses or comments on the article can be found at the end of the article. STUDY PROTOCOL The perspectives of patients and their caregivers on self-management interventions for chronic conditions: a protocol for a mixed-methods overview [version 1; peer review: awaiting peer review] Ena Niño de Guzmán , Laura Martínez-García , Ana I. González , Monique Heijmans , Jorge Huaringa , Kaisa Immonen , Lyudmil Ninov , Carola Orrego-Villagrán , Javier Pérez-Bracchiglione , Karla Salas-Gama , Andrés Viteri-García , Pablo Alonso-Coello 1,3 Iberoamerican Cochrane Centre, Sant Pau Biomedical Research Institute (IIB-Sant Pau), Barcelona, 08025, Spain Universitat Autònoma de Barcelona, Barcelona, Spain CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain Avedis Donabedian Research Institute (FAD), Barcelona, 08037, Spain Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Madrid, Spain Netherlands institute for health services research (Nivel), Utrecht, 3513, The Netherlands Hospital Arzobispo Loayza, Lima, Lima 15082, Peru European Patients’ Forum, Brussels, 1040, Belgium Interdisciplinary Centre for Health Studies (CIESAL), Universidad de Valparaíso, Valparaíso, 2520000, Chile Hospital Santa Creu i Sant Pau, Barcelona, 08025, Spain Universidad UTE, Quito, 170527, Ecuador Cochrane Ecuador, Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC), Quito, 170527, Ecuador Abstract : Self-management (SM) interventions are complex Introduction interventions and one of the main components of high-quality chronic disease care for which the incorporation of the perspectives of patients and their informal caregivers is crucial. We aim to identify, appraise and synthesise the evidence exploring patients’ and caregivers’ perspectives on SM interventions. More precisely, we aim to 1) describe how they value the importance of outcomes of SM interventions, and 2) identify the factors that might impact on acceptability and feasibility of SM interventions based on their preferences and experiences. : We will conduct four mixed-methods overviews as Methods and analysis part of COMPAR-EU, a European Union (EU) funded project aimed to identify the most effective and cost-effective SM interventions for chronic obstructive pulmonary disease (COPD), heart failure (HF), obesity, and type 2 diabetes mellitus (T2DM). We will search in MEDLINE, CINAHL, and PsycINFO for systematic reviews of studies addressing patients’ preferences on outcomes, or their experiences with SM alongside their disease trajectory or with SM interventions, published in English. Selection 1,2 1,3 4,5 6 7 8 8 2,4,5 9 10 11,12 1,3 1 2 3 4 5 6 7 8 9 10 11 12 Reviewer Status AWAITING PEER REVIEW 18 Feb 2020, :120 ( First published: 9 ) https://doi.org/10.12688/f1000research.22125.1 18 Feb 2020, :120 ( Latest published: 9 ) https://doi.org/10.12688/f1000research.22125.1 v1 Page 1 of 11 F1000Research 2020, 9:120 Last updated: 20 FEB 2020