Kulkarni P K et al., Int. J. Res. Pharm. Sci., 2020, 11(1), 730-746 ORIGINAL ARTICLE INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACEUTICAL SCIENCES Published by JK Welfare & Pharmascope Foundation Journal Home Page: www.pharmascope.org/ijrps Formulation and evaluation of different topical dosage forms for wound healing properties Dandasi Jayachandra Dev, Jayaprakash J S, Kulkarni P K * , Akhila A R, Namratha S Saraf Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, JSS Medical Campus, Sri Shivarathreeshwara Nagara, Mysuru – 570015, Karnataka, India Article History: Received on: 04.07.2019 Revised on: 16.10.2019 Accepted on: 28.10.2019 Keywords: wound, β cyclodextrin, phosphatidylcholine, cholesterol ABSTRACT The aim of the present work was to compare the wound healing efϑicacy of dif- ferent topical dosage forms such as β cyclodextrin complex gel, liposomal gel, and ointment on the rat model. Simvastatin was used as a drug, β cyclodextrin was used as a complexing agent to enhance solubility, L α Phosphatidylcholine as a phospholipid, and cholesterol as a stabilizing agent. Liposomes were pre- pared by thin-ϑilm hydration method, β cyclodextrin complexes of simvastatin were prepared by spray drying technique, and the ointment was prepared in simple method. Beta cyclodextrin gels and liposomal gels were prepared by direct incorporation of spray-dried products and lyophilized liposomes into Carbopol gel. The gel was evaluated for drug content, particle size, viscosity, spreadability, surface morphology, in-vitro drug release studies, skin irrita- tion study, and wound healing activity studies. FTIR and DSC studies showed no chemical interaction between the drug and excipients. The particle size of β cyclodextrin complexes was in the range of 0.5 μm to 2.5 μm and for lipo- somes 163 nm to 725 nm. The in-vitro drug release was 96.7 % at the end of the sixth hour for β cyclodextrin gel, 29.7 % at the end of the sixth hour for liposomal gel, and 96.2 % at the end of 3 hours for ointment. Wound healing activity studies were carried out for 21 days on albino wrister rats, a period of epithelization, and rate of wound contraction was measured on 4, 8, 14, 16, and 21 days. Simvastatin ointment showed a signiϑicant effect on wound heal- ing in the rat model compared to β -cyclodextrin gel and liposomal gel. Hence, Simvastatin ointment could be a potential dosage form for clinical utility on wound healing. * Corresponding Author Name: Kulkarni P K Phone: Email: pkkkulkarni@jssuni.edu.in ISSN: 0975-7538 DOI: https://doi.org/10.26452/ijrps.v11i1.1886 Production and Hosted by Pharmascope.org © 2020 | All rights reserved. INTRODUCTION A wound may be characterized as a disturbance of normal skin tissue structure due to physical or thermal damage or due to the existence of an underlying medical or physical condition and func- tion and maybe classiϑied by etiology, position or length. (Dhivya et al., 2015).Wound healing includes a series of well-orchestrated biochemical and cel- lular events leading to clear growth and regen- eration of wounded tissue, including coagulation, inϑlammation, the formation of granulated tissue, epithelization, collagen synthesis, and tissue remod- eling (Gonzalez, 2016). There are several topical solutions available to treat 730 © International Journal of Research in Pharmaceutical Sciences