Jemds.com Original Research Article J. Evolution Med. Dent. Sci./eISSN- 2278-4802, pISSN- 2278-4748/ Vol. 7/ Issue 30/ July 23, 2018 Page 3352 HISTOPATHOLOGICAL SPECTRUM OF HYSTERECTOMY SPECIMENS- A RETROSPECTIVE ANALYSIS AT IGIMS, PATNA, BIHAR Zeenat Sarmadi Imam 1 , Kalpana Chandra 2 , Monalisa 3 , Bipin Kumar 4 , Anshuman Sinha 5 , Anju Singh 6 , Sanjeet Kumar Singh 7 , Shuchismita 8 1 Senior Resident, Department of Pathology, IGIMS, Patna, Bihar, India. 2 Assistant Professor, Department of Pathology, IGIMS, Patna, Bihar, India. 3 Senior Resident, Department of Pathology, IGIMS, Patna, Bihar, India. 4 Professor, Department of Pathology, IGIMS, Patna, Bihar, India. 5 Senior Resident, Department of Pathology, IGIMS, Patna, Bihar, India. 6 Associate Professor, Department of Pathology, IGIMS, Patna, Bihar, India. 7 Associate Professor, Department of Pathology, IGIMS, Patna, Bihar, India. 8 Assistant Professor, Department of Pathology, IGIMS, Patna, Bihar, India. ABSTRACT BACKGROUND Uterus is subjected to many benign and malignant diseases, which are managed by medical and surgical methods. In this study we analysed the spectrum of morphological changes noted in the hysterectomy specimen received in our department. We also emphasised the relevance of histopathology in every case and highlighted any incidental findings including non-neoplastic and neoplastic lesions. MATERIALS AND METHODS This is a retrospective descriptive study. We included a total of 220 hysterectomy samples received in the Pathology Department of Indira Gandhi Institute of Medical Sciences from January 2015 to December 2016. Cases were selected as per inclusion and exclusion criteria. All the details were collected from histopathology request form and hospital record sheet. Gross and microscopic features were analysed and recorded. RESULTS We included a total of 220 hysterectomy specimens. 161 cases had undergone total abdominal hysterectomy and 59 cases had undergone simple hysterectomy. The most common age group was in the age range of 41 - 50. The most common pathological findings in the myometrium was leiomyoma (29.04%) followed by adenomyosis (11.69%). In cervix, the common histopathological finding was chronic cervicitis (91.81%). Squamous cell carcinoma in cervix was 6.36%. In ovaries, non-neoplastic cystic lesions were in 10% cases. Other benign tumours include mature cystic teratoma (1.81%), mucinous cystadenoma (1.81%) and serous cystadenoma (4.09%). In malignant counterpart, serous cystadenocarcinoma and mucinous cystadenocarcinoma are 4.09% and 1.81% respectively. One case of collision tumour and one case of Krukenberg tumour were noted. CONCLUSION Hysterectomy is a treatment modality for benign as well as malignant clinical conditions. The increasing incidences of malignant neoplasm of various sites of female genital tract emphasise the relevance of histopathological analysis of all surgical specimens, which can aid in further management and prognostication. KEY WORDS Histopathology, Hysterectomy, Leiomyoma. HOW TO CITE THIS ARTICLE: Imam ZS, Chandra K, Monalisa, et al. Histopathological spectrum of hysterectomy specimens- a retrospective analysis at IGIMS, Patna, Bihar. J. Evolution Med. Dent. Sci. 2018;7(30):3352-3355, DOI: 10.14260/jemds/2018/756 BACKGROUND Hysterectomy is the most commonly performed major gynaecological surgery throughout the world. [1] Uterus is subjected to many benign and malignant diseases and for this many treatment options are available including medical and conservative surgical. Hysterectomy remains as one of the most successful operations in terms of symptoms relief, ‘Financial or Other Competing Interest’: None. Submission 11-06-2018, Peer Review 08-07-2018, Acceptance 14-07-2018, Published 23-07-2018. Corresponding Author: Dr. Kalpana Chandra, Assistant Professor, Department of Pathology, Indira Gandhi Institute of Medical Sciences, Patna-800014, Bihar, India. E-mail: kalpana_chandra_14@yahoo.co.in DOI: 10.14260/jemds/2018/756 patient’s satisfaction, improvement in quality of life and providing definite cure to many non-neoplastic lesions of uterus such as fibroids, dysfunctional uterine bleeding, uterine prolapse, endometriosis, adenomyosis etc. [2] At many times, hysterectomy has been proved as life-saving procedure. On the top of above-mentioned justification for hysterectomy, a substantial increase in hysterectomies has been noted owing to the prophylaxis against uterine cancer. Histopathological study of specimen remains the gold standard, as it carries diagnostic as well as therapeutic significance. It also aids in planning management of malignant lesion if found any. In this study, we want to discuss the histomorphological spectrum of lesions in the hysterectomy specimen received at our institute. We also want to emphasise on the relevance of histopathology in every case and highlight any incidental findings including non-neoplastic and neoplastic lesions.