January 2020 · Volume 9 · Issue 1 Page 318 International Journal of Reproduction, Contraception, Obstetrics and Gynecology Mitra B et al. Int J Reprod Contracept Obstet Gynecol. 2020 Jan;9(1):318-322 www.ijrcog.org pISSN 2320-1770 | eISSN 2320-1789 Original Research Article A study on feto-maternal outcome of intra hepatic cholestasis of pregnancy Binay Mitra, Debkalyan Maji*, D. S. Borse INTRODUCTION Pregnancy brings several reversible and irreversible changes to maternal physiology during its course. Almost all maternal systems undergo some kind of adaptation to pregnancy. Hepatobiliary system also undergoes several changes which can be appreciated clinically and biochemically. Intra Hepatic cholestasis of pregnancy (IHCP) is one such liver disorder which is unique to pregnancy. IHCP is found among all ethnic groups with marked variation in incidence. It affects 0.2-2% of pregnant women worldwide. 1 IHCP cases are almost double in Asian women compared to European women. The highest incidence of IHCP (~4%) was found in indigenous women from Chile and Bolivia. 2 The maternal complication associated with IHCP are increased risks of post-partum haemorrhage, operative delivery, severe pruritus with dyslipidemia and deranged coagulation profile, preterm prelabour rupture of membrane. 3 IHCP is associated with increased risk of adverse perinatal outcomes like spontaneous preterm birth, meconium staining of the amniotic fluid and stillbirth. 4 ABSTRACT Background: Intrahepatic cholestasis of pregnancy is one kind of the hepatic disorder which is unique to pregnancy. It is associated with many adverse pregnancy outcomes if doesn’t intervened at right time. It requires adequate clinico-biochemical correlation during management. Methods: A prospective observational study was conducted at multispecialty government zonal hospital. Total 137 IHCP patients were managed during the study period from 01 Jan 2017 to 30 Jun 2019. Incidence and pregnancy outcome in form of several maternal and fetal factors were analysed by appropriate statistical test using spps software version 20.0. Results: During the study period total 4872 patients were undergoing delivery and 137 patients were diagnosed with IHCP. The incidence of IHCP was 2.81%. Majority of cases 75 out 137 (54.74%) were nulligravida. Total 29.92% (41/137) cases were underwent LSCS delivery and of this 21.17% (29/137) were primary caesarean delivery. There were three still birth noted in IHCP study population. Total 28 cases (20.44%) of IHCP were presented with preterm labour. And NICU admissions of the study population were 32 new born babies (23.36%). 2.18% case of still birth was noted among study population. Conclusions: IHCP causes significant maternal and neonatal morbidity and is major contributor of preterm delivery, caesarean delivery, meconium stained liquor and NICU admission. Keywords: Antenatal care, Intrahepatic cholestasis of pregnancy, Obstetric choloestasis Department of Obstetrics and Gynecology, 166 Military Hospital, Jammu, Jammu and Kashmir, India Received: 11 November 2019 Accepted: 03 December 2019 *Correspondence: Dr. Debkalyan Maji, E-mail: dr.debkalyan@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20196041