Journal Pre-proof NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington’s disease mouse model Daniele Moretti, Sara Tambone, Mauro Cerretani, Paola Fezzardi, Antonino Missineo, Leticia Toledo Sherman, Ignacio Munoz-sajuan, Steven Harper, Celia Dominquez, Robert Pacifici, Licia Tomei, Larry Park, Alberto Bresciani PII: S0891-5849(20)31296-X DOI: https://doi.org/10.1016/j.freeradbiomed.2020.10.022 Reference: FRB 14873 To appear in: Free Radical Biology and Medicine Received Date: 7 August 2020 Revised Date: 12 October 2020 Accepted Date: 18 October 2020 Please cite this article as: D. Moretti, S. Tambone, M. Cerretani, P. Fezzardi, A. Missineo, L.T. Sherman, I. Munoz-sajuan, S. Harper, C. Dominquez, R. Pacifici, L. Tomei, L. Park, A. Bresciani, NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington’s disease mouse model, Free Radical Biology and Medicine, https://doi.org/10.1016/ j.freeradbiomed.2020.10.022. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Published by Elsevier Inc.