This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/JDV.16871 This article is protected by copyright. All rights reserved DR. CLAUDIA CÉCILE VALÉRIE LANG (Orcid ID : 0000-0003-0469-7661) DR. GE TAN (Orcid ID : 0000-0003-0026-8739) DR. MARIE-CHARLOTTE BRUEGGEN (Orcid ID : 0000-0002-8607-6254) Article type : Letter to Editor Evidence for different immune signatures and sensitization patterns in sub- Saharan versus central European Atopic Dermatitis patients Key words: Atopic dermatitis, sub-Saharan Africa, sensitization patterns, immune phenotypes Word count: 600; table count: 1; figure count: 1 CCV Lang, 1, 2 J Masenga, 3 G Semango, 3 H Kaderbhai, 3 N Li, 1,2 G Tan, 4,5 A Heider, 4 E Guttmann-Yasski, 6 F Grimm, 7 P Schmid-Grendelmeier, 1,2 MC Brüggen 1, 2, 8 1 Dpt of Dermatology, University Hospital Zurich, Zurich, Switzerland; 2 Faculty of Medicine, University of Zurich, Zurich, Switzerland; 3 Regional Dermatology Training Center (RDTC) at KCMUC, Moshi, Tanzania 4 Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland 5 Functional Genomics Center Zurich, ETH Zurich/University of Zurich, Zurich, Switzerland 6 Dpt of Dermatology, Mount Sinai Hospital New York, New York, USA 7 Institute for Parasitology, University of Zurich, Zurich, Switzerland 8 Hochgebirgsklinik Davos, Davos, Switzerland Corresponding author’s address: Prof. Marie-Charlotte Brüggen; MD PhD Medical Campus Davos Herman-Burchard-Strasse 1 CH- 7265 Davos-Wolfgang, Switzerland Tel.: +41 44 255 11 11; Fax: +41 44 255 43 45 E-Mail: marie-charlotte.brueggen@usz.ch Accepted Article