Open Forum Infectious Diseases MAJOR ARTICLE 1 DOI: 10.1093/ofid/ofad238 Enterococci in diabetic foot infections: Prevalence, Clinical Characteristics, and Outcomes Ofer Perzon 1,6* , Avivit Cahn 2,6* , Yechiel N Gellman 3,6 , Michal Leibovitch 4 , Shahar Peled 4 , Ofer Elishoov 3,6 , Amir Haze 3,6 , Karen Olshtain-Pops 5,6** , Hila Elinav 5,6** 1 Department of Internal medicine, Hadassah Hebrew University Medical Center, Ein Kerem – Jerusalem, Israel; 2 Diabetes Unit, Department of Endocrinology and Metabolism, Hadassah Hebrew University Medical Center, Ein Kerem – Jerusalem, Israel; 3 Diabetic Foot Unit, Department of Orthopedics, Hadassah Hebrew University Medical Center, Ein Kerem – Jerusalem, Israel; 4 Department of Military Medicine and “Tzameret”, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel, and Medical Corps, Israel Defense forces, Israel; 5 Department of Clinical Microbiology and Infectious diseases, Hadassah Hebrew University Medical Center, Ein Kerem – Jerusalem, Israel; 6 The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. Background: Diabetic foot infections (DFI) are frequently polymicrobial, yet the relevance of each isolated pathogen, remains ill-defined. Specifically, the prevalence and pathogenicity of enterococcal DFI, and impact of targeted anti-enterococcal treatment, remain elusive. Methods: We collected demographic, clinical and outcome-related data on patients admitted with DFI to the Hadassah Medical Center diabetic foot unit between 2014-2019. The primary outcome was a composite of in-hospital mortality or major amputation. Secondary outcomes included any amputation, major amputation, length of stay (LOS), and 1-year major amputation or mortality. —————————————————————————————————————— * These two authors contributed equally to the study ** These authors contributed equally to the study Correspondence to: Ofer Perzon, M.D., Internal Medicine B department, Hadassah Hebrew University Hospital, Jerusalem, The Hebrew University of Jerusalem, Ein Kerem. P.O. Box 12271, Jerusalem, 9112102 Israel, E-mail: ofer.perzon@gmail.com; Phone number: +972545860709 © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com ACCEPTED MANUSCRIPT Downloaded from https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofad238/7148321 by guest on 04 May 2023