IIAGG 2017 World Congress MIDLIFE NEIGHBORHOOD SOCIOECONOMIC STATUS AND 20-YEAR CHANGE IN COGNITION: THE ARIC-NCS STUDY A. Kucharska-Newton 3 , M. Patel 2 , P. Palta 3 , T.H. Mosley 1 , G. Heiss 3 , 1. University of Mississippi, Jackson, Mississippi, 2. Symphony Health Solutions, Conshohocken, Pennsylvania, 3. University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Studies of the association between socioeconomic status (SES) and cognitive function have mostly focused on indi- vidual attributes to defne SES (e.g. education, income), while few have examined the association of contextual SES charac- teristics with age-related change in cognitive function. Using data from the biracial Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS), we exam- ined the association of ZIP code-level median household income, assessed at mid-life, with 20-year change in cog- nition from mid-life through older adulthood. Cognition was assessed in 13,881 men and women at baseline (1990– 1992; median age: 57.3 years, 44.3% men, 23.7% African American) and at two subsequent examinations (1996–1998 and 2011–2013) using the Delayed Word Recall Test, Digit Symbol Substitution Test, and the Word Fluency Test, stand- ardized to the baseline scores. Standardized test scores were then averaged to yield a global cognition domain z score. Multiple imputation by chained equations was used to impute cognitive test scores missing due to attrition. Using random effects mixed models, adjusted for age, gender, race, and individual-level educational attainment, we observed that the magnitude of the rate of change in global cognition during a median 20.8 years of follow-up was simi- lar across distribution-based tertiles of median household income (high SES: β=-0.99 (95% CI -1.00, -0.99); middle SES: β=-0.96 (95% CI -0.97, -0.96); low SES β=-0.96 (95% CI -0.96, -0.95)). Our fndings suggest that mid-life neigh- borhood SES is not associated with the rate of cognitive decline through older adulthood. RELATIONSHIP OF GLOBAL CARDIOVASCULAR RISK AND MIDLIFE PHYSICAL PERFORMANCE IN A BI-RACIAL COHORT B.D. Pollock 1 , P. Stuchlik 1 , J.M. Guralnik 2 , J. Gustat 1 , L.S. Webber 1 , W. Chen 1 , E.W. Harville 1 , L. Bazzano 1 , 1. Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, 2. University of Maryland School of Medicine, Baltimore, Maryland Evidence has suggested the existence of a bi-directional relationship between cardiovascular disease and physical per- formance in elderly adults, with several potential common mechanisms including chronic infammation and sarcope- nia. Yet, there remains little data on the relationship between CVD risk and physical performance in mid-life. The objective of this study was to determine if global cardiovascular risk measures were associated with score on the short physical performance battery (SPPB) in a mid-life cohort of African- American and white adults followed since childhood. Our study included 845 participants of the Bogalusa Heart Study cohort. We separately examined the relationships between both 10-year AtheroSclerotic CardioVascular Disease (ASCVD) and Framingham CHD risks and poor physical performance, defned as SPPB<10, in logistic regression models, controlling for educational attainment, as a surrogate of socioeconomic status, alcohol, and body mass index. Mean (SD) age was 48.4 (4.9); 63.2% of were women and 33.5% were African- American. A total of 173 (19.8%) participants demonstrated poor physical performance, with median (IQR) ASCVD 10-year risk and Framingham risks of 5.6% (2.3%-11.7%) and 2.5%(0.9%-6.4%), respectively versus 3.1% (1.3%-6.1%) and 1.3%(0.5%-4.8%) in those with good physical perfor- mance (p<.0001 and p<.001, respectively). These relationships both persisted (p<.01) after adjustment. These results indicate that global cardiovascular risk is strongly linked to physical performance measures, even in a relatively low-risk, mid-life population. Given this strong association, mid-life cardiovas- cular risk scores which are commonly calculated in primary care settings may aid in the early identifcation of individuals who may beneft from interventions designed to prevent frailty. PRESCRIBED MEDICATION AND MALNOURISHMENT AT RISK OF MALNUTRITION A. Maseda 1 , A. Bujn 1 , L. Lorenzo-López 1 , R. López- López 1 , V. Valdiglesias 2 , B. Laffon 2 , J. Millán-Calenti 1 , 1. Gerontology Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), SERGAS, Universidade da Coruña, A Coruña, Spain, 2. DICOMOSA Group, Department of Psychology, Area of Psychobiology, Universidade da Coruña, A Coruña, Spain Malnutrition is a common health problem in polymedi- cated older adults. This cross-sectional study investigates the relationship between the prescribed medication and malnourishment/risk of malnutrition. The research was con- ducted in a representative sample of 749 community-dwelling elders aged 65 years and over, showing a combined preva- lence for the malnourished/ at risk of malnutrition group of 14.3% (assessed by the short form of the Mini Nutritional Assessment, MNA-SF). Each medication was categorized according to the Anatomical Therapeutical Chemical (ATC) classifcation. Low MNA-SF score group (≤11 points) consumed a higher number of medications (6.5 ± 3.5 vs. 4.5 ± 3.2, p<0.001) and presented higher polypharmacy (5 or more, 64.5% vs. 40.0%, p<0.001). The most common drug classes in malnourished/at risk of malnutrition participants were cardiovascular (76.6%), alimentary tract and metabo- lism (70.1%) and nervous system (68.2%). Stepwise logistic regression analyses revealed that no consuming alimentary tract and metabolism (adjusted OR 1.61; 95% CI 1.01 to 2.56), blood and blood forming organs (adjusted OR 1.69; 95% CI 1.09 to 2.60) and nervous system (adjusted OR 2.16; 95% CI 1.38 to 3.38) drug classes was related to lower MNA-SF scores. Therefore, the consumption of these medica- tions is associated with the presence/absence of malnutrition. These fndings reveal the importance of a correct prescribed medication related to the most frequent health problems in older adults to avoid the presence of malnourishment/ risk of malnutrition and to propose appropriate intervention. Funding: Xunta de Galicia (GPC2014/082) Innovation in Aging, 2017, Vol. 1, No. S1 802 Downloaded from https://academic.oup.com/innovateage/article/1/suppl_1/802/3899937 by guest on 18 June 2023