Acta Scientific Pharmaceutical Sciences (ISSN: 2581-5423) Volume 5 Issue 12 December 2021 Green Synthesis of Zinc Oxide Nanoparticles Using Hydro Methanolic Extract of Flueggea leucopyrus Willd Fruit J Vinnarasi 1 *, A Anto Arockia Raj 2, M Augustin 3 and G Revathi 1 1 Department of Chemistry, The Standard Fireworks Rajaratnam College for Women (Autonomous), Sivakasi, Tamil Nadu, India 2 Department of Chemistry, St. Xavier’s College (Autonomous), Palayamkottai, Tamil Nadu, India 3 Department of Physics, St. Xavier’s College (Autonomous), Palayamkottai, Tamil Nadu, India *Corresponding Author: J Vinnarasi, Assistant Professor, Department of Chemistry, The Standard Fireworks Rajaratnam College for Women (Autonomous), Sivakasi, Tamil Nadu, India. Research Article Received: October 12, 2021 Published: November 15, 2021 © All rights are reserved by J Vinnarasi., et al. Abstract Biosynthesis of nanoparticle is a vital role in the field of nanotechnology. In the present study zinc oxide nanoparticles synthesis were mediated by green synthesis using hydro methanolic extract of Flueggea leucopyrus Willd fruit. The green synthesized ZnO nanoparticles were analysed by UV-Vis, FT-IR Spectroscopy, X-Ray Diffraction and Scanning Electron Microscopy. The results of the various techniques confirmed the formation of ZnO-NPs. The UV-Vis spectra exhibited the absorption maximum at 360 nm corre- sponds to pure ZnO-NP. FT-IR spectra revealed the presence of stretching vibrations of -O-H, C-H, C-N, C=O and Zn-O involved in the reduction and stabilisation of nanoparticles. The SEM and XRD confirmed the synthesised ZnO-NPs is hexagonal (Wurtzite) shaped and size about 87.59 nm. The antioxidant property was reported using DPPH Radical Scavenging activity. The maximum concentra- tion of ZnO-NPs was shown a promising antioxidant value of 71.22 ± 1.61 comparable with the standard vitamin-C. The current study is an attempt to describe an effective, simple and eco-friendly method of ZnO-NPs and to appraise its potential for various therapeutic applications in future. Keywords: F. leucopyrus Fruit; ZnO-NP; XRD; SEM; DPPH Radical Introduction Nanotechnology is one of the emerging fields in 21 st century. Nanoparticles are very small sized particles with enhanced cata- lytic reactivity, thermal conductivity, non-linear optical perfor- mance and chemical steadiness owing to its large surface area to volume ratio [1]. Transition metal oxide with nano structure and semiconductors with nano dimensions have attracted consider- able interest in numerous areas of science and technology as next generation technologies [2-4]. Nowadays Zinc Oxide nanoparticles are very much essential in various streams of science. Zinc oxide is the most promising inorganic oxides that are extensively used owing to its suitable magnetic, electrical and optical properties [5]. ZnO has been listed as “Generally Recognized as safe” (GRAS) by the US Food and Drug Administration (FDA 21CFR182.8991) [6]. It crystallizes in two main forms, hexagonal Wurtzite and cubic Zinc blende [7]. Traditionally, ZnO nanoparticles are synthesized us- ing physical and chemical processes, which offer higher produc- tion rate and produce the better-controlled size of nanoparticles. Nonetheless, these methods are considered unfavourable due to high capital cost, high energy requirements and involve the use of toxic and hazardous chemicals. Consequently, these features result in secondary pollution to the environment. Moreover, a study dem- Citation: J Vinnarasi., et al. “Green Synthesis of Zinc Oxide Nanoparticles Using Hydro Methanolic Extract of Flueggea leucopyrus Willd Fruit". Acta Scientific Pharmaceutical Sciences 5.12 (2021): 42-46.