Home | About PR | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us | Login Search Article Advanced search Users Online:12 Antioxidant, cytotoxic, antitumor, and protective DNA damage metabolites from the red sea brown alga Sargassum sp Seif - Eldin N Ayyad 1 , Saleh T Ezmirly 1 , Salim A Basaif 1 , Walied M Alarif 2 , Adel F Badria 3 , Farid A Badria 4 1 Department of Chemistry, Faculty of Science, King Abdul Aziz University, P. O. 80203, Jeddah 21589, Saudi Arabia 2 Department of Marine Chemsitry, Faculty of Marine Sciences, King Abdulaziz University, Jeddah 21589, P O 80207, Saudi Arabia 3 Tissue Engineering Lab., Faculty of Dentistry, Alexandria University, Alexandria, Egypt 4 Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt Correspondence Address: Seif-Eldin N Ayyad Faculty of Sciences, King Abdulaziz University, Jeddah Saudi Arabia DOI: 10.4103/0974-8490.85000 PMID: 22022163 Background: Macroalgae can be viewed as a potential antioxidant and anti-inflammatory sources owing to their capability of producing compounds for its protection from environmental factors such as heat, pollution, stress, oxygen concentration, and UV radiations. Objective: To isolate major compounds which are mainly responsible for the pharmacological activity of brown alga under investigation, Sargassum sp. Materials and Methods: Algal material was air dried, extracted with a mixture of organic solvents, and fractionated with different adsorbents. The structures of obtained pure compounds were elucidated with different spectroscopic techniques, and two pure materials were tested for protection of DNA from damage, antioxidant, antitumor, and cytotoxicity. Results: Four pure compounds were obtained, of which fucosterol (1) and fucoxanthin (4) were tested; it was found that fucoxanthin has strong antioxidant and cytotoxicity against breast cancer (MCF-7) with IC 50 = 11.5 ΅g/ml. Conclusion: The naturally highly conjugated safe compound fucoxanthin could be used as antioxidant and as an antitumor compound. Keywords: Antioxidant, cytotoxicity, fucoxanthin, Sargassum sp ORIGINAL ARTICLE Year : 2011 | Volume : 3 | Issue : 3 | Page : 160-165 Date of Submission 01-Feb-2011 Date of Decision 06-Apr-2011 Date of Web Publication 16-Sep-2011 Abstract How to cite this article: Ayyad SN, Ezmirly ST, Basaif SA, Alarif WM, Badria AF, Badria FA. Antioxidant, cytotoxic, antitumor, and protective DNA damage metabolites from the red sea brown alga Sargassum sp. Phcog Res 2011;3:160-5 How to cite this URL: Ayyad SN, Ezmirly ST, Basaif SA, Alarif WM, Badria AF, Badria FA. Antioxidant, cytotoxic, antitumor, and protective DNA damage metabolites from the red sea brown alga Sargassum sp. Phcog Res [serial online] 2011 [cited 2012 Jun 4];3:160-5. Available from: http://www.phcogres.com/text.asp?2011/3/3/160/85000 Search GO Similar in PUBMED Search Pubmed for z Ayyad SN z Ezmirly ST z Basaif SA z Alarif WM z Badria AF z Badria FA Search in Google Scholar for z Ayyad SN z Ezmirly ST z Basaif SA z Alarif WM z Badria AF z Badria FA Related articles z Antioxidant z cytotoxicity z fucoxanthin z Sargassum sp Access Statistics Email Alert * Add to My List * * Registration required (free) In this article Abstract Introduction Materials and Me... Results and Disc... Acknowledgment References Article Figures Article Tables Article Access Statistics Viewed 656 Printed 28 Emailed 2 PDF Downloaded 8 Comments [Add] Cited by others 1 Total downloads in last 2 months Jun 2012 5 May 2012 71 Click here to download free Android Application for this and other journals Click here to view o