Clinics of Oncology Review Article ISSN: 2640-1037 Volume 3 COVID-19: More Tan A Lung Infection Shiha G 1,2, * , Mousa N 3 , Abdel-Razik A 3 , Elhammady D 3 , Elshennawy H 4 , El-Farrash M 5,6 , Mousa E 7 , Taha A 8 , El-bendary M 3 and Eslam M 9 1 Departments of Internal Medicine, Mansoura University, Egypt 2 Egyptian Liver Research Institute and Hospital (ELRIH), Sherbin, Mansoura University, Egypt 3 Departments of Tropical Medicine, Mansoura University, Egypt 4 Departments of Internal Medicine, National Liver Institute, Egypt 5 Department of Microbiology, Mansoura University, Egypt 6 Horus University, Egypt 7 Faculty of Dentistry, Mansoura University, Egypt 8 Faculty of Medicine, October 6 University, Egypt 9 Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, NSW, Australia Received: 17 Oct 2020 Accepted: 03 Nov 2020 Published: 08 Nov 2020 Copyright: ©2020 Shiha G et al. Tis is an open access article dis- tributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commer- cially. Citation: Shiha G, COVID-19: More Tan A Lung Infection. Clinics of Oncology. 2020; 3(3): 1-8. Keywords: Coronavirus; COVID-19; Pneumonia; Digestive system; Cardiovascular system; Coagulopathy vascular endothelial system 1. Abstract COVID-19 is a new strain of Coronaviruses virus declared by the World Health Organization (WHO) as a pandemic on March 11th, 2020. While the majority of patients with COVID-19 typically have characteristic respiratory presentations subsequently, a large number of patients were presented with multi-system afection, particularly digestive system, liver, cardiovascular, cutaneous, co- agulopathy, vascular, endothelial, central nervous, oral cavity and renal systems. Of note the mortality and the need for mechanical ventilation were higher in old age and patients with comorbidi- ties especially obesity, which can shif the risk of COVID-19 to a younger age. Tis review article will attain to summarize the liter- ature published to date concerning diferent body system afection of COVID-19. 2. Introduction It wasn’t until the end of December of 2019 that the World Health Organization (WHO) was notifed of the afection of a large num- ber of patients with an obscure form of unidentifed pneumonia in the Chinese city of Wuhan and the Hubei region [1]. Tis severe acute respiratory syndrome was later attributed to an original coro- navirus namedSARS-CoV-2, [2] defned by its extensively high communicability leading to its very rapid worldwide spread [3, 4]. Due to these factors WHO on March 11th, 2020, declared SARS- CoV-2as a pandemic of global proportion for only the second time in the past century afer the H1N1 infuenza pandemic [5]. Coronaviruses (CoVs) receive their name due to the presence of surface crown-like spikes. Tese viruses form part of the Corona- virinae subfamily, subdivided by phylogenetic clustering into α, β, γ, and δ groups; human infection is caused by group α and βCoVs [6]. Coronaviruses are single-stranded positive-sense RNA viruses [7], that consist of major proteins specifed as the S, or spike pro- tein responsible for connecting to the host receptor allowing union between the cell membrane and virus, the N (nucleocapsid) pro- tein, the M (membrane) protein, and the E (envelope) protein [8]. Isolation of coronaviruses can occur from a number of diferent clinicsofoncology.com 1 * Corresponding author: Gamal Shiha, Department of Internal Medicine, Faculty of Medicine, Mansoura University, Egyptian Liver Research Institute and Hospital (ELRIAH), Mansoura, Egypt, Tel: +2 01223280501; Email: g_shiha@hotmail.com