Ebselen inhibits mycobacterial ESX-1 secretion through modification of EccA1 Morwan M. Osman a,e , Malte L. Pinckert a,c,e , Sew Peak-Chew b , Mark A. Troll a , William H. Conrad a,d, *, Lalita Ramakrishnan a * a Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. b MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK c Present address: Division of Virology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Cambridge, CB2 0QQ, UK d Present address: Department of Chemistry, Lake Forest College, Lake Forest, Illinois 60045, USA e M.M.O. and M.L.P. Contributed equally to this work. * Correspondence: Lalita Ramakrishnan, lr404@cam.ac.uk; William Conrad, conrad@lfc.edu Author contributions: M.M.O., W.H.C., and L.R. designed the research; M.M.O., M.L.P., S.P.C., and W.H.C. performed research; M.M.O., M.L.P., S.P.C., M.A.T., and W.H.C. analyzed data; M.M.O., M.L.P., and L.R. wrote the paper. . CC-BY-NC-ND 4.0 International license not certified by peer review) is the author/funder. It is made available under a The copyright holder for this preprint (which was this version posted November 2, 2019. . https://doi.org/10.1101/828574 doi: bioRxiv preprint