COMMENTARY Prevention and Treatment of SARS-CoV2 Infection in People Living with HIV: The Need for Specific Data Natalia A. Dı ´az . Rosa de Miguel . Fernando Agu ¨ero . Omar Sued . Jose ´ R. Arribas . Juan Ambrosioni . the Hospital Clinic COVID-19 in HIV Investigators Received: October 1, 2021 / Accepted: October 5, 2021 Ó The Author(s) 2021 ABSTRACT The HIV pandemic has led to close to 40 million people living with HIV (PLWH) worldwide. To date, SARS-CoV2 has affected [ 220 million people, and unprecedented global efforts have resulted in almost 6000 million doses of SARS- CoV2 vaccines being administered. Although several specific COVID-19 antiviral and anti- inflammatory treatments and SARS-CoV2 vac- cines have been approved, the data available to support their use in specific populations such as PLWH remain limited. PLWH includes a range of individuals from practically unaffected immunity to severely immunocompromised individuals, and preventive and therapeutic interventions should be tailored for these sub- groups . However, in most randomized clinical trials regarding antivirals, immunomodulators and vaccines for COVID-19, PLWH have been excluded or only enrolled in small numbers leading to a paucity of data. We briefly discuss the current evidence for prevention and treat- ment of COVID-19 in PLWH and identify key areas where more information is required. Keywords: COVID-19; HIV; HIV infection; PLWH; Prevention; SARS-CoV2; SARS-CoV2 vaccines; Treatment Natalia A. Dı ´az and Rosa de Miguel contributed equally to and are co-first authors of this manuscript. Members of the Study Group are listed in the appendix. Supplementary Information The online version contains supplementary material available at https:// doi.org/10.1007/s40121-021-00547-y. N. A. Dı ´az Infectious Diseases Service, Hospital Cuenca Alta, Can ˜ uelas, Argentina R. de Miguel Á J. R. Arribas Infectious Diseases Unit, Hospital Universitario La Paz, Madrid, Spain F. Agu ¨ero Preventive Medicine Service, Hospital Universitario Bellvitge, Barcelona, Spain O. Sued Fundacio ´n Hue ´sped, Buenos Aires, Argentina J. Ambrosioni (&) HIV Unit and Infectious Diseases Service, Hospital Clinic-IDIBAPS, Villarroel 170, 08036 Barcelona, Spain e-mail: ambrosioni@clinic.cat; jambrosioni@intramed.net Infect Dis Ther https://doi.org/10.1007/s40121-021-00547-y