Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2015, 7(4):838-841 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 838 A study on antimicrobial and anthelmintic activity of methanolic leaf extracts of Syzygium malaccense (L.) Merr. & Perry Aiswarya Purushothaman 2 , A. Sangita Sudhir 2 , Gleena Joby 2 , Aravind R. 1 and Alexeyena Varghese* 1 1 Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwavidhyapeetham University, AIMS Health Sciences Campus, Kochi, Kerala, India 2 Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita Vishwavidhyapeetham University, AIMS Health Sciences Campus, Kochi, Kerala, India _____________________________________________________________________________________________ ABSTRACT Traditional plants are the potential sources of many potent and powerful drugs. They represent a rich source of antimicrobial and anthelmintic activity. The development of resistance and high cost of conventional synthetic drugs have paved the way to the evaluation of alternative source of medicines. The present study was undertaken to evaluate antimicrobial and anthelmintic activity of methanolic extract of leaves of Syzygium malaccense (L.) Merr. & Perry. Antimicrobial activity was evaluated against clinically important Proteus bacteria and Candida albicans using Kirby-Bauer disk diffusion method. The result showed that extract have moderate degree of both antibacterial and antifungal activity. The anthelmintic activity was carried as per method of Ajaiyeoba et al, which involves determination of time of paralysis and time of death of earthworm (Pheretima posthuma). The result showed that extract, revealed a concentration dependent anthelmintic activity. Keywords: Anthelmintic activity, Methanolic Extract, Myrtaceae, antimicrobial, Syzygium malaccense _____________________________________________________________________________________________ INTRODUCTION Syzygium malaccense (L.)Merr. & Perry is a small tree indigenous to regions of Malaysia and South East Asia [1]. It is mainly found in lowland to mountain rain forest [2], [3]. The tree is valued for its large edible fruits. The fruit of the plant is often called as ‘Malay Apple’. The fruit of the plant is often called as ‘Malay Apple’. They are widely used in traditional medicines for mouth infections, throat infections, stomach ache and abdominal ailments [4], [5]. Crushed leaves are used as antiemetic, purgative and also to treat bronchitis, tongue inflammation, dysentery, constipation, diabetes, cough, pulmonary cataract, headache and other ailments [6]. Since no report has been found on anthelmintic and anti microbial property, the present study is conducted to evaluate these properties. EXPERIMENTAL SECTION Collection and Authentication The leaves of the plant Syzygium malaccense (L.)Merr. &Perry (Family: Myrtaceae) was collected from Ernakulum district, Kerala, India in September 2014. The fresh leaves were taxonomically identified by Botanist. The authentification of the plant was done by Mrs.Leela.M, Botany Department, Paliyam Government Higher Secondary School, Paravur , Cochin, Kerala, India.