Clinicopathologic challenge Clustered yellowish papules on the cheek Reem Osama, MSc, Heba A. Abdelkader, MD Soha Ahmad, MBBCh and Mona R. E. Abdel-Halim, MD, Dip Dermpath (ICDP-UEMS) Department of Dermatology, Faculty of Medicine, Kasr Alainy Hospital, Cairo University, Cairo, Egypt Correspondence Heba A. Abdelkader, MD Dermatology Department Kasr Al Aini Hospital Cairo University Kasr Al Aini Street Cairo 11562 Egypt E-mail: h_abdelkader2007@yahoo.com Conflict of interest: None. Funding source: None. doi: 10.1111/ijd.14906 What is your diagnosis? Clinical findings A 31-year-old female presented with a yellowish/red plaque on the left cheek that developed shortly after birth, gradually Figure 2 Photomicrograph depicting histopathological changes. (a) Unremarkable epidermis and grouped mature hyperplastic sebaceous lobules in the dermis opening into a central dilated duct associated with a hair follicle (Hematoxylin and eosin, x25). (b) Higher magnification showing hyperplastic sebaceous lobules (Hematoxylin and eosin, x100) enlarged, then became stationary. The patient had no family history of a similar condition, no other relevant medical symp- toms, and the lesion was asymptomatic. On examination, the plaque consisted of multiple coalescing yellowish-red papules with central puncta (depressions) (Fig 1). No other skin lesions were found elsewhere anywhere in the body. Histopathological findings A 3 mm punch skin biopsy was taken from the lesion and revealed unremarkable epidermis with no hyperkeratosis, papil- lomatosis, or acanthosis and grouped mature hyperplastic seba- ceous lobules in the dermis opening into a central dilated duct associated with a hair follicle (Fig 2). Figure 1 Yellowish/red plaque on the left cheek composed of multiple coalescing yellowish-red papules with central puncta (depressions) ª 2020 the International Society of Dermatology International Journal of Dermatology 2020 1