TAHUN 2022 TAHUN 2023 [MANUJU: MALAHAYATI NURSING JOURNAL, ISSN CETAK: 2655-2728 ISSN ONLINE: 2655-4712, VOLUME 5 NOMOR 6 JUNI 2023] HAL 1650-1659 1650 HUBUNGAN ANTARA NEUTROPHIL LYMPHOCYTE RATIO DAN HCV RNA PADA PASIEN HEPATITIS C MENJALANI HEMODIALISIS YANG MENDAPATKAN TERAPI DAA DI RSMH PALEMBANG Lilis Khairani 1* , Suyata 2 , Novadian 3 , Taufik Indra Jaya 4 1-4 Fakultas Kedokteran Universitas Sriwijaya/RSUP Dr. Moh. Hoesin Email Korespondensi: Lilis.khairani90@gmail.com Disubmit: 15 Desember 2022 Diterima: 04 Februari 2023 Diterbitkan: 01 Juni 2023 Doi: https://doi.org/10.33024/mnj.v5i6.8668 ABSTRACT Hepatitis C is an inflamamatory disease of the liver caused by Hepatitis C Virus (HCV) infection. Inflammatory markers are quite large in assessing the course of an infectious or inflammatory disease, one of which is the Neutrophil Lymphocyte Ratio (NLR) and the Total Viral Load of HCV RNA which combine neutrophils as active inflammatory components and lymphocytes as regulatory and protective components in a single parameter. Research on the relationship between NLR and HCV RNA in Hepatitis C outpatients undergoing hemodialysis is still limited. Therefore, this study was conducted to determine the relationship between NLR and HCV RNA in Hepatitis C patients undergoing hemodialysis who received DAA therapy who went to the outpatient clinic at Mohammad Hoesin Hospital, Palembang. Observational analytic study with a cross-sectional design with 35 Hepatitis C patients undergoing hemodialysis as subjects who were treated at the outpatient polyclinic at Mohammad Hoesin Hospital Palembang in August – November 2022. Data were obtained by recording from medical records. The data is on a categorical scale and tested using the Sperman correlation method using the SPSS version 22 application. The average NLR of Hepatitis C patients undergoing hemodialysis who had not received DAA therapy at RSMH Palembang with a high HCV RNA viral load and high NLR was 17 (12.6%) and those with low viral load and high NLR were 4 (8.4%). In addition, it is also known that the average NLR of Hepatitis C patients undergoing hemodialysis who received DAA therapy for 12 weeks at RSMH Palembang whose HCV RNA Viral Load was undetectable and the NLR was normal was 24 (24.9%) and the Viral Load was still detectable and the NLR was normal was 6 ( 5.1%). The results of the analysis showed a p value = 0.000 with a value of r = 0.738 for the relationship between NLR and HCV RNA values in patients who had not started DAA therapy and the results of the analysis showed a p value = 0.005 with a value of r = 0.50 for the relationship between NLR and HCV RNA values in patients who have received DAA therapy for 12 weeks to correlate NLR and HCV RNA values in Hepatitis C patients undergoing hemodialysis. This study showed that there was a moderately significant relationship between NLR and HCV RNA values in Hepatitis C patients undergoing hemodialysis who received DAA therapy at Mohammad Hoesin Hospital, Palembang. Keywords: Hepatitis C, Hemodialysis, NLR, HCV RNA