International Journal of Otorhinolaryngology and Head and Neck Surgery | February 2021 | Vol 7 | Issue 2 Page 308 International Journal of Otorhinolaryngology and Head and Neck Surgery Ankle NR et al. Int J Otorhinolaryngol Head Neck Surg. 2021 Feb;7(2):308-312 http://www.ijorl.com pISSN 2454-5929 | eISSN 2454-5937 Original Research Article Evaluation of graft uptake using temporalis fascia and cartilage perichondrium supplemented with autologous platelet rich plasma in tympanoplasty N. R. Ankle, Rajesh Radhakrishna Havaldar, Sweta Sinha* INTRODUCTION Temporalis fascia remains the most frequently used graft material with closure of the tympanic membrane in 70% to 90% of primary tympanoplasties in different hands. However, in some situations such as advanced middle ear pathology, retraction pockets, and atelectatic ears, temporalis fascia tends to undergo atrophy in the subsequent postoperative period regardless of placement techniques. 1 Our dissatisfaction with the temporalis fascia with a higher incidence of recurrent perforations compelled us to use a tougher material that would not only prevent reperforation but also prevent retractions. Cartilage has shown to be a promising graft material to close perforations in the tympanic membrane. Although it is similar to temporalis fascia, its more rigid quality tends to resist resorption, retraction, and reperforation, even in the milieu of continuous eustachian tube dysfunction. 2 ABSTRACT Background: Tympanoplasty involves grafting the perforation of the tympanic membrane with materials such as temporalis fascia, cartilage perichondrium, periosteum, vein, fat etc. Both temporalis fascia and cartilage perichondrium are easy to harvest with minimum donor site complications and both have been used extensively in tympanoplasty. Platelet rich plasma aids as an adhesive and supplements healing by providing growth factors. Till date there is scarcity of literature comparing the healing outcome of both cartilage perichondrium and temporalis fascia supplemented with platelet rich plasma. Hence, in this study we are comparing cartilage perichondrium supplemented with platelet rich plasma and temporalis fascia supplemented with platelet rich plasma. Methods: An observational study involving 60 patients was done. Patients with chronic otitis media were evaluated by otoendoscopy to assess the ear and were categorised into 2 groups which received temporalis fascia and cartilage perichondrium respectively. All cases were supplemented with platelet rich plasma. Post-operative assessment was done by otoendoscopy. Results: Total 21 patients received temporalis fascia and 39 patients received cartilage perichondrium. At the end of 6 weeks the graft site appeared unhealthy in 6.66% cases who received temporalis fascia and 1.66% in those who received cartilage perichondrium. Conclusions: We found that cartilage perichondrium supplemented with platelet rich plasma had a better uptake after 6 weeks due to its superior mechanical stability. The results are more rewarding than the use of temporalis fascia with platelet rich plasma. Keywords: Temporalis fascia, Tympanoplasty, Cartilage perichondrium, Platelet rich plasma Department of ENT and Head and Neck Surgery, J. N. Medical College, Belagavi, Karnataka, India Received: 03 November 2020 Revised: 24 December 2020 Accepted: 26 December 2020 *Correspondence: Dr. Sweta Sinha, E-mail: swetaankita@yahoo.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: https://dx.doi.org/10.18203/issn.2454-5929.ijohns20210162