_____________________________________________________________________________________________________ *Corresponding author: E-mail: madeehamalik19@gmail.com; Journal of Pharmaceutical Research International 34(51A): 25-38, 2022; Article no.JPRI.92006 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Quality of Life (QoL) and Psychological Distress among Congestive Heart Failure Patients: A Prospective Observational Study from Pakistan Rana Umar Shahzad a , Madeeha Malik b* , Azhar Hussain c and Ayisha Hashmi b a Hamdard Institute of Pharmaceutical Sciences, Hamdard University Islamabad, Pakistan. b Cyntax Health Projects, Contract Research Organization, Islamabad, Pakistan. c Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology, Haripur, Pakistan. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2022/v34i51A7201 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/92006 Received 17 July 2022 Accepted 21 September 2022 Published 06 October 2022 ABSTRACT Introduction: Congestive Heart failure (CHF) is a cardiovascular disease harming the physical, social, psychological, emotional, and well-being status of an individual. The interference due to symptoms and signs of heart failure affects QoL (QoL) and leads to depression among the majority of the patients. Objective: To assess the QoL and depression among CHF patients in Pakistan. Methodology: A descriptive cross-sectional study design was used to assess the QoLand depression among CHF patients in Pakistan. The study population included CHF patients greater than 18 years old, both genders visiting public and private Health Care Facilities located in twin cities of Pakistan. QoL was assessed by using SF 36 and KCCQ while HADS (hospital anxiety and depression scale) was used to evaluate the Depression among 382 CHF patients selected using the convenience sampling technique. Data was entered in SPSS version 21 and statistically analyzed. Results: The results highlighted that use of SF-36 showed the lowest scores for QoL in the domain of role physical (8.82, ± 8.23) followed by the domain of role emotional (10.17, ± 8.6) whereas the highest scores were observed in the domain of mental health (67.26, ± 15.67). On the other hand, Original Research Article