1 Tumor edge architecture in glioblastoma is constructed by inter-cellular signals 1 from vascular endothelial cells 2 3 Authors: 4 Soniya Bastola 1, 5 †, Marat S. Pavlyukov 2 †, Yasmin Ghochani 3 , Sree Deepthi Muthukrishnan 3 , 5 Hee Jin Cho 4 , Yeri Lee 4 , Alireza Sohrabi 5 , Stephanie K. Seidlits 5, 6 , Daisuke Yamashita 7 , Min 6 Soo Kim 1, 3 , Ksenia S. Anufrieva 8 , Riki Kawaguchi 9 , Yue Qin 9 , Alma L Burlingame 10 , Juan A. 7 Oses-Prieto 10 , Steven A. Goldman 11 , Anita B. Hjelmeland 12 , Do-Hyun Nam 13 , Harley I. 8 Kornblum 1, 15 *, and Ichiro Nakano 5, 14, 15 * 9 10 Affiliations: 11 1 Graduate Biomedical Sciences, University of Alabama at Birmingham, AL 35294, USA 12 2 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia 13 3 The Intellectual and Developmental Disabilities Research Center, The Semel Institute for 14 Neuroscience and Human Behavior, and The Broad Stem Cell Research Center, The Jonsson 15 Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 16 90095, USA 17 4 Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351, Korea 18 5 Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, 19 USA 20 6 Jonsson Comprehensive Cancer Center, Broad Stem Cell Research Center, Brain Research 21 Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA 22 7 Department of Neurosurgery, Ehime University, Japan 23 8 Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal 24 Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological 25 Agency, Moscow, Russia 26 9 Semel Institute for Neuroscience and Human Behavior, Departments of Psychiatry and 27 Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, 28 USA 29 10 Department of Pharmaceutical Chemistry, University of California, San Francisco, San 30 Francisco CA 94158, USA 31 . CC-BY-NC-ND 4.0 International license available under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made The copyright holder for this preprint this version posted October 12, 2020. ; https://doi.org/10.1101/2020.10.12.335091 doi: bioRxiv preprint