_____________________________________________________________________________________________________ *Corresponding author: E-mail: augustineairaodion@yahoo.com; International Journal of Research and Reports in Hematology 4(1): 30-41, 2021; Article no.IJR2H.66256 Effect of Bambara Nut Consumption on Blood Glucose Level and Lipid Profile of Wistar Rats Anthony U. Megwas 1 , Patricia N. Akunne 2 , Nathaniel O. Oladosu 3 , Oladeji J. Alabi 4 , Onyinyechi C. Njoku 5 and Augustine I. Airaodion 5* 1 Department of Optometry, Federal University of Technology, Owerri, Imo State, Nigeria. 2 Department of Biochemistry, University of Benin, Edo State, Nigeria. 3 Department of Mathematics, Educational Advancement Centre, Ibadan, Oyo State, Nigeria. 4 Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. 5 Department of Biochemistry, Federal University of Technology, Owerri, Imo State, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. Author AIA designed the study and wrote the manuscript. Author AUM carried out the analyses of the study. Authors PNA and OCN managed the literature searches, Author NOO managed the statistical analysis while, author OJA wrote the protocol of the study. All authors read and approved the final manuscript Article Information Editor(s): (1) Dr. Juan Carlos Troiano, University of Buenos Aires, Argentina. Reviewers: (1) Joan C. Escolà-Gil, Universitat Autònoma de Barcelona (UAB), Spain. (2) Seyed Mahmoud Latifi, Ahvaz Jundishapur University of Medical sciences, Iran. Complete Peer review History: http://www.sdiarticle4.com/review-history/66256 Received 03 January 2021 Accepted 09 March 2021 Published 18 March 2021 ABSTRACT Aim: This study sought to investigate the effect of Bambara nut consumption on blood glucose level and lipid profile of Wistar rats. Methodology: The Songkhla 1 variety (red seed coat) of Bambara nuts were locally sourced from Obinze area of Owerri, Imo State, Nigeria. The seeds were peeled and ground to a fine powder using a coffee grinder and extracted using soxhlet apparatus and methanol as the solvent. Twenty- four adult male Wistar rats were acclimatized for seven days during which they were fed ad libitum with standard feed and drinking water. They were randomly divided into four groups of six rats each. Rats in group A were administered distilled water while those in groups B, C and D were administered 100, 200 and 400 mg/kg body weight of Bambara nut extract 12 hourly for twenty-one days via oral route of administration. At the end of 21 days of treatment, animals were sacrificed Original Research Article