European Journal of Molecular & Clinical Medicine ISSN 2515-8260 Volume 07, Issue 06, 2020 187 Effect of BergeniaLigulata on Metabolic Enzymes of Glucose Homeostasis and Its Correlation With Antioxidant Activity in Streptozotocin Induced Diabetic Rats Nagarani K 1 , Swathi P 2 , Eswar Kumar K 3 1,3 A.U.College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh 2 Research Scholar, JNTUK, Kakinada, Andhra Pradesh e-mail: ekilari@gmail.com Abstract: Diabetes mellitus is characterized by loss of glucose homeostasis as a result of impaired secretion and function of insulin. The present study was designed to evaluate the role of flower extractof Bergenialigulataagainst diabetesin Streptozotocin induced diabetic rats. Albino Wistar rats weighing 120-150g of either sex were selected for the study.After a week of acclimatization, the rats were subjected to overnight fasting. Diabeteswas induced by intraperitoneal injection of Streptozotocin, freshly dissolved in citrate bufferpH 4.5.In the present study the STZ control animals showed enhanced gluconeogenic enzymes and diminished glycolytic enzymes there by it disturb the glucose homeostasis and diminished insulin production leads increased serum glucose levels. Treatment with flower extract ofBergenialigulata(AFBL) showed significant balancing of glucose homeostasis through reduction in gluconeogenic enzymes and elevation of glycolytic enzymes.The selected flower extract ofBergenialigulata(AFBL) showed in vivo antioxidant activity, antihyperglycemic activity, hepatoprotective activity, nephroprotective activity and finally glucose homeostatic activity might be due to the potent phytoconstituents present in the selected flower extract. Keywords: Bergenialigulata; Streptozotocin; wistarrats; diabetes mellitus 1. INTRODUCTION Diabetes mellitus is characterized by loss of glucose homeostasis as a result of impaired secretion and function of insulin. Insulin deficiency causes an imbalance in glucose metabolism and other sources of energy such as lipids and proteins 1 and varies from type 1, type 2 and other types of diabetes. With type 2 diabetes, insulin instability and deficiency lead to a decrease in glucose intake in the liver, tissues and adipose tissue, therefore, the contributing action of insulin directly affects glucose production and utilization in the liver. Glucose is the most common substrate for energy metabolism. Indeed, under normal circumstances glucose is the only energy source that can be used by the brain and the central nervous system 2 . The amount of glucose in a cycle depends on the ratio of the amount of glucose entering the cycle (the appearance of sugar) and the rate of removal of glucose from the circulation (disappearance of sugar). Plasma glucose concentration is maintained through intestinal absorption, glycogenolysis, glycogen depletion, which is a form of sugar storage, and gluconeogeneis, glucose formation mainly from lactate, glycerol and amino acids during fasting 3 . Maintenance of normal