International Journal of Research in Medical Sciences | October 2020 | Vol 8 | Issue 10 Page 3624 International Journal of Research in Medical Sciences Utaal SKD et al. Int J Res Med Sci. 2020 Oct;8(10):3624-3628 www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 Original Research Article Association of ocular biometric parameters with diabetic retinopathy Shubhneek Kaur Dhillon Utaal * , Rupali Chopra, Nitin Batra INTRODUCTION Individuals with diabetes mellitus (DM) are 25 times more likely to become legally blind than others. 1 Visual loss is primarily the result of progressive diabetic retinopathy (DR) and clinically significant macular edema (CSME). Various studies have suggested that myopia, particularly of high degree, may have a protective effect on DR. 2 Myopia has two components: structural {Axial length (AL) and Anterior chamber depth (ACD)} and refractive {Corneal curvature (CC) and Spherical equivalent (SE)}. It is unclear as to which component is the main contributor to the relationship of refractive errors with DR. 3 Among the components of myopia, AL has received the most attention. 4 Since ACD is a part of AL, apparently the major protective effect may be related to the length of the vitreous chamber. 5 These relationships, however, have not been firmly established. This study has been carried out to evaluate the association between the various ocular biometric parameters and the presence as well as different grades of DR. Department of Ophthalmology, Christian Medical College & Hospital, Ludhiana, India Received: 02 Aug 2020 Accepted: 05 Sep 2020 *Correspondence: Dr. Shubhneek Kaur Dhillon Utaal, E-mail: drshubhneek@hotmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: To study the association of ocular biometric parameters {Spherical equivalent (SE), Axial length (AL), Anterior chamber depth (ACD) and Corneal curvature (CC)} with diabetic retinopathy (DR) in subjects with Type 2 diabetes mellitus (DM). Methods: This prospective observational study was conducted in the Outpatient Department of Ophthalmology of a tertiary care teaching hospital in North India. The study included 100 subjects having various grades of DR as cases and 100 diabetics without DR as controls. The SE was assessed using objective autorefraction, while AL, CC and ACD were measured using the NIDEK AL SCAN. International Clinical Diabetic Retinopathy Disease Severity Scale was used for grading of DR. Results: A total of 181 eyes in the study group and 200 eyes in the control group were analysed. Progressive decrease in the mean AL was observed with the increasing severity of DR (p=0.017). Deeper ACD had a negative correlation with severity of DR (p=0.037). No statistically significant difference was observed for AL and ACD with the incidence of DR (p=0.147 and p=0.091 respectively). Likewise, there was no significant relation of DR with SE or CC. Conclusions: Longer AL and deep ACD were protective against progression to the severe forms of DR. However, there was no correlation of AL and ACD with the incidence of DR. The SE and CC were not found to be significant determinants for either development or severity of DR. Keywords: Anterior chamber depth, Axial length, Corneal curvature, Diabetes mellitus, Diabetic retinopathy, Myopia, Spherical equivalent DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20204240