1 Control of mammalian brain ageing by the unfolded protein response transcription factor XBP1 Authors: Felipe Cabral-Miranda 1,2,3,4 , Giovanni Tamburini 1,2,3 , Gabriela Martinez 1,2,3 , Danilo Medinas 1,2,3 , Yannis Gerakis 1,2,3 ,Tim Miedema 1,2,3 , Claudia Duran-Aniotz 1,2,3 , Alvaro O. Ardiles 5,6 , Cristobal Ibaceta-Gonzalez 5 , Carleen M. Sabusap 7 , Francisca Bermedo-Garcia 8 , Stuart 5 Adamson 9 , Kaitlyn Vitangcol 9 , Hernan Huerta 10 , Xu Zhang 11 , Tomohiro Nakamura 11 , Sergio Pablo Sardi 12 , Stuart A. Lipton 11,13 Brian K. Kenedy 9,14 , Julio Cesar Cárdenas 2,10 , Adrian G. Palacios 5 , Lars Plate 7 , Juan Pablo Henriquez 8 , and Claudio Hetz 1,2,3,9 *. Affiliations: 1. Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile. 10 2. Center for Geroscience, Brain Health and Metabolism, Santiago, Chile. 3. Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile. 15 4. Instituto de Ciências Biomédicas, Universidade do Rio de Janeiro, Rio de Janeiro, Brazil. 5. Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaiso, Valparaiso, Chile. 20 6. Centro de Neurología Traslacional, Escuela de Medicina, Universidad de Valparaíso, Valparaiso, Chile. 7. Department of Chemistry, Vanderbilt University, Nashville, TN, USA. 25 8. Department of Cell Biology, Center for Advanced Microscopy (CMA BioBio), Universidad de Concepción, Concepción, Chile 9. Buck Institute for Research on Aging, Novato, CA, USA. 30 10. Center for Integrative Biology, Universidad Mayor, Santiago, Chile. 11. Department of Molecular Medicine and Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037, USA 35 12. Rare and Neurological Diseases Therapeutic Area, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA 13. Department of Neurosciences, University of California, San Diego, School of Medicine, La 40 Jolla, CA 92093, USA 14. Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.