Citation: Kordas, G. The Nano4XX Nanotechnology Platform: The Triumph of Nanotechnology. Nanomanufacturing 2023, 3, 228–232. https://doi.org/10.3390/ nanomanufacturing3020014 Received: 12 May 2023 Accepted: 17 May 2023 Published: 22 May 2023 Copyright: © 2023 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Editorial The Nano4XX Nanotechnology Platform: The Triumph of Nanotechnology George Kordas 1,2 1 Sol-Gel Laboratory, NCSR Demokritos, 15310 Agia Paraskevi, Greece; gckordas@gmail.com 2 Self-Healing Structural Materials Laboratory, World-Class Scientific Center of the Federal State Autonomous Educational Institution of Higher Education, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia If a person is diagnosed with cancer, doctors recommend surgery, chemotherapy, and radiotherapy [1]. In the case of chemotherapy, there are visible and invisible phenomena that no one can avoid. Some are visible, such as hair loss, and others are hidden, such as heart toxicity. How can we target the cancer but leave the organs untouched by these toxic chemicals? To date, no one has considered that cancer differs from healthy organs. Cancer has a temperature of 37 degrees Celsius, the redox is different from the rest of the organs, and its pH is between 3.8 and 4.5 [1]. If we want to develop drugs that target cancer, we need to consider these parameters and create drug delivery systems that recognize these cancer properties. If a drug transporter also has a targeting molecule, then in this way, we will target the tumor and get the best results. We need to give these drug delivery bodies the ability to automatically target and recognize cancer on their own so that we get the best results, namely targeted chemotherapy. Drug carriers were developed for this purpose and consist of three shells, i.e., three different polymers. The first polymer is sensitive to pH, the second polymer is temper- ature sensitive, and the third polymer is susceptible to cancer redox. These carriers are charged with bulk chemotherapy drugs that are commercial. The surface of these carriers is equipped with magnetic nanoparticles so that they can be used for hyperthermia. Addition- ally, these drug carriers are fitted with gadolinium so that we can observe them using the Magnetic Resonance Imaging (MRI) technique. Finally, we equip the drug delivery systems with fluorescent probes to monitor them using fluorescence spectroscopy. Figure 1 shows such a DDS comprising three shells [2]. These DDSs are overloaded with doxorubicin, cisplatin, etc. A targeting molecule is placed on the surface of the DDS to find breast cancer via folic acid and prostate cancer via leuprolide [3]. A scientist developing such a new DDS must solve several challenges and determine if one can exploit this DDS commercially. The first questions we must answer are whether this drug delivery system is toxic, whether it enters the cancer cell, and how it is dispersed in the body; in addition, we must discover its toxicity to various organs and, finally, whether there is a treatment [4–7]. In other words, the inventor must prove that this new drug delivery system solves all the problems of chemotherapy and leads to better therapeutic results. Because the system we developed has a quadruple response to cancer, we named it Nano4XX; XX is the commercial drug we charge it: doxorubicin, cisplatin, etc. A key question is whether this platform enters cancer. This question was answered with the two experiments illustrated in Figure 2. For these experiments, we used the platform, which in one case had no folic acid targeting molecules (Figure 2A), while in the second, we used a platform modified superficially with folic acid (Figure 2B). In the first case, we see that the platform is piled out of the cancer cells, as shown by the green light emanating from the Fitc. In the second case, the platform surrounds the cancer cells and colors them green because of the Fitc, and because they enter the cancer cells, we see them Nanomanufacturing 2023, 3, 228–232. https://doi.org/10.3390/nanomanufacturing3020014 https://www.mdpi.com/journal/nanomanufacturing