_____________________________________________________________________________________________________ *Corresponding author: E-mail: imohjohnny@uniuyo.edu.ng; Asian Journal of Biology 14(1): 6-24, 2022; Article no.AJOB.81900 ISSN: 2456-7124 Pharmacognostic Characterization of Cola millenii K. Schum. (Malvaceae) Imoh I. Johnny a* , Uwemedimo F. Umoh a , Romanus A. Umoh a , Mfon F. Alozie b Aniefiok S. Udobre c , Arnold C. Igboasoiyi c , Margaret E. Bassey d , Nsima A. Andy a , Inyang J. Udo e and Omodot T. Umoh d a Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria. b Department of Pharmaceutical Microbiology and Biotechnology Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria. c Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, Akwa Ibom State, Nigeria. d Department of Botany and Ecological Studies, Faculty of Sciences, University of Uyo, Akwa Ibom State, Nigeria. e Akwa Ibom State Polytechnic, Ikot Osurua, Ikot Ekpene, Akwa Ibom State, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. Authors MEB and ASU supervised the author IIJ who carried out the bench work and wrote the first draft of the manuscript. Authors RAU, UFU, ACI, MFA, NAA, IJU and OTU managed the literature search. Author MEB perfected the final manuscript which was approved by all authors for publication. Article Information DOI: 10.9734/AJOB/2022/v14i130202 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/81900 Received 03 November 2021 Accepted 07 January 2022 Published 10 January 2022 ABSTRACT Background: Cola millenii K. Schum. is a member of Cola which is lesser-known in the family Malvaceae. The leaf is used in the treatment of ringworm, scabies, gonorrhoea, diarrhoea, cough and ophthalmia by the locals. Aim: The study determines various taxonomic, pharmacognostic and phytochemical standards helpful to ensure the identity, purity, safety and efficacy of the medicinal plant, C. millenii. Methodology: The pharmacognostic characterization was determined following the guidelines given by the World Health Organization (WHO). Parameters determined included macroscopy, Original Research Article