BIODIDAKTIKA: Jurnal Biologi dan Pembelajarannya, Vol.18, No.1, 2023, pp. 9-23 e-ISSN 2527-4562. DOI. 10.30870/biodidaktika.v18i1.17808 9 The Effect of Interactive Multimedia on Students’ Cognitive Learning Outcomes on System Materials Submitted 26 November 2022, Revised 17 January 2023, Accepted 17 January 2023 Fajriani Asysyura 1* , Adnan Adnan 2 , Faisal Faisal 3 1,2,3 Department of Biology Education, Faculty of Mathematics and Nature Sciences, Universitas Negeri Makasar, Makasar, Indonesia Corresponding Email: *fajrianiasysyura@gmail.com Abstract This study aimed to determine the influence of interactive multimedia on students' cognitive learning outcomes in class XI. This study employed a quasi-experimental method using Posttest-Only Control Design. The population is students of class XI MIPA. Samples were taken by random sampling; an experimental class that uses interactive multimedia with as many as 30 students and a control class that does not use interactive multimedia with as many as 30 students. The data collection technique is carried out by providing a post-test to obtain data on student cognitive learning outcomes, and the data analysis technique used is an independent sample t-test with a significant level (α) = 5%. Based on data analysis and hypothesis testing, it shows that there is an influence of interactive learning multimedia on cognitive learning outcomes because of the significant value of 0.000 < 0.05. There are differences in student results, which can be seen through hypothesis tests that H0 is rejected and Hi is accepted. Students accept the use of interactive multimedia in the classroom in carrying out the teaching and learning process. Based on the study results, it was concluded that interactive learning multimedia influences the cognitive learning outcomes of class XI students. Keyword: Interactive multimedia, cognitive learning outcomes, digestive system material INTRODUCTION Today's prevailing slant in interactive media applications for industry and society is the ever-growing scale of media collections. As the common open has been given apparatuses for phenomenal media generation, capacity, and sharing, media era and utilization have expanded definitely in later a long time. Besides, up and coming mixed media applications in incalculable domains—from shrewd urban spaces and trade insights to wellbeing and wellness, lifelogging, and entertainment— progressively require joint displaying of numerous modalities (Khan et al., 2020). According to Muhsetyo (2008), media is a learning aid that is deliberately and planned, prepared by teachers to the student, or explains lesson materials and is used by students to be able to engage directly with learning. One learning media for students that offers a direct virtual experience is interactive multimedia, a learning media designed for independent learning, creating a fun learning environment and motivating students in the classroom. Learning media has a function to convey learning messages and clarify the presentation of messages, overcome the limitations of space and time and allow for more varied and passionate teaching and learning interactions. The use of learning media is expected to positively influence student learning outcomes to achieve the desired learning goals (Arsyad, 2010).