World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Available online at: http://www.wjpsonline.org/ Original Article Address for Correspondence: Dr. Krishnaraju Venkatesan, Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, KSA; Email: kvenkatesan@kku.edu.sa How to Cite this Article: Premalatha Paulsamy, Krishnaraju Venkatesan, Kalpana Krishnaraju, Saravanan VS, Manimekalai Pichaivel, Divya Kuppan. Effect of Terminalia Arjuna on dead space wound in diabetic rats. World J Pharm Sci 2021; 9(8): 106-109. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial- ShareAlike 4.0 International License, which allows adapt, share and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. © 2013-21 World J Pharm Sci Effect of Terminalia Arjuna on dead space wound in diabetic rats Premalatha Paulsamy 1 , Krishnaraju Venkatesan 2* , Kalpana Krishnaraju 3 , Saravanan VS 3 , Manimekalai Pichaivel 4 , Divya Kuppan 5 1 King Khalid University, Khamis Mushayit, Asir Province, Saudi Arabia 2 Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, KSA 3 Department of Pharmacy, Erode College of Pharmacy, Veppampalayam, Erode, India 4 Professor & Head Department of Pharmacology, SVCP, Tiruchengode, Tamil Nadu, India 5 JKK Nataraja College of arts and science, Kumarapalayam, Namakkal District, India Received: 11-06-2021 / Revised Accepted: 23-07-2021 / Published: 27-07-2021 ABSTRACT The effects of Terminalia arjuna (T.arjuna) on the healing of rat cutaneous wounds were studied in diabetic rats utilising an in vivo dead space wound model. On each axilla of diabetic rats, dead space incisions were created. For eight days, the rats were randomly assigned to one of three treatment groups (Group I: Normal saline; Group II: Diabetic control; Group III: B.lanzan). Animals were euthanized on day 10, and cotton pellets and granuloma tissues were carefully collected and processed for further estimates. The tensile strength of the dead space wounds increased statistically significantly, according to the findings. When the hexosamine content of granulation tissue produced from dead space wounds was compared to the control, the hexosamine concentration was found to be higher. In addition, as compared to the control, the levels of hydroxyproline, hexuronic acid, tissue protein, and lysyl oxidase were considerably higher. These findings support the use of T.arjuna, which is primarily composed of tannins, to speed up the healing process. As a result, the current study backs up the plant's wound healing claims in diabetic wounds. Key words: T.arjuna, Wound healing; Diabetic; Dead space wound; Granulation tissue; Streptozotocin INTRODUCTION Therapeutic properties have been found for Terminalia arjuna (Combretaceae). The bark of the T.Arjuna tree has been used in Ayurvedic medicine for over three centuries, notably as a heart tonic. It is also claimed to enhance the skin and cleanse the blood. T.Arjuna bark has previously been utilised to aid wound healing in rat incision and excision wound models. 1,2 The researchers discovered that