Journal Pre-proof Inhibition of the transcriptional repressor LexA: Withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials Pierangelo Bellio, Alisia Mancini, Letizia Di Pietro, Salvatore Cracchiolo, Nicola Franceschini, Samantha Reale, Francesco de Angelis, Mariagrazia Perilli, Gianfranco Amicosante, Francesca Spyrakis, Donatella Tondi, Laura Cendron, Giuseppe Celenza PII: S0024-3205(19)31043-4 DOI: https://doi.org/10.1016/j.lfs.2019.117116 Reference: LFS 117116 To appear in: Life Sciences Received date: 9 October 2019 Accepted date: 27 November 2019 Please cite this article as: P. Bellio, A. Mancini, L. Di Pietro, et al., Inhibition of the transcriptional repressor LexA: Withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials, Life Sciences(2019), https://doi.org/10.1016/ j.lfs.2019.117116 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2019 Published by Elsevier.