Int.J.Curr.Microbiol.App.Sci (2023) 12(06): 202-215 202 Original Research Article https://doi.org/10.20546/ijcmas.2023.1206.025 Use of Entomopathogenic Bacteria Bacillus thuringiensis in the Republic of Uzbekistan: Problems and Prospects Dilorom B. Turabekova 1 , Nortoji A. Khujamshukurov 2* , Dmitry V. Voitka 3 , Dilafruz Kh. Kuchkarova 4 , Feruza A. Mustafaqulova 5 , Feruzakhon N. Abdikholikova 6 and Saidkamol Xaydarov 7 1 Tashkent Institute of Chemical Technology, Uzbekistan 2 Research Institute of Plant Genetic Resources Uzbekistan, Tashkent Institute of Chemical Technology, Uzbekistan 3 Lab. of Microbiological Method of Plant Protection against Pests and Diseases, Institute of Plant Protection, Belarus 4 Tashkent University of Architecture and Civil Engineering, Uzbekistan 5 Namangan Engineering and Technology Institute, Uzbekistan 6 Tashkent State Agrarian University, Uzbekistan 7 Fergana State University, Uzbekistan *Corresponding author ABSTRACT Introduction Considering that according to statistics, the population of the Republic of Uzbekistan is increasing by 650-670 thousand people per year, it will reach 47 million by 2026. This shows that the population's demand for agricultural products will increase several hundred times. In particular, the day by day increasing demand for environmentally friendly products requires reducing the amount of The Republic of Uzbekistan is a country specializing in agriculture, with favorable climatic conditions that allow high yields of almost all types of crops.At the moment, in our republic, 1 million 387 thousand hectares of land is used for growing cotton, about 1 million 700 thousand hectares of grain products (including 1 million 200 thousand hectares of irrigated areas), more than 560 thousand hectares of fruits and vegetables and products horticulture, and 967.8 1000 hectares are specialized in growing fodder plants. In the absence of large losses in the cultivation and storage of agricultural products, this amount of land would be enough to freely provide the population of the republic with food and technical raw materials and export some of the products. This article provides analytical information about the work carried out on the basis of the entomopathogenic bacterium Bacillus thuringiensis in the protection of agricultural crops from harmful insects. Information is also provided on the production of - exotoxin, L-exotoxin, -exotoxin, -exotoxin, crystalline -endotoxin and their classification. Keywords Microbiological biopreparations, Bacillus thuringiensis, entomopathogenic bacteria, crystal toxin Received: 15 April 2023 Accepted: 02 June 2023 Available Online: 10 June 2023 Article Info International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 12 Number 6 (2023) Journal homepage: http://www.ijcmas.com