Pharmaciana Vol.6, No.2, November 2016, Hal. 139-148 ISSN: 2088 4559; e-ISSN: 2477 0256 DOI: 10.12928/pharmaciana.v6i2.4078 139 Journal homepage: http://journal.uad.ac.id/index.php/PHARMACIANA Formulasi dan evaluasi granul effervescent ekstrak daun binahong (Anredera cordifolia (Tenore) Steen.) Indah Fortuna Rahmawati, Prasojo Pribadi, Imron Wahyu Hidayat DIII Farmasi, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Magelang Jl. Mayjend Bambang Soegeng, Mertoyudan, Magelang Submitted: 02-05-2016 Reviewed: 05-11-2016 Accepted: 03-11-2016 ABSTRAK Penelitian ini bertujuan untuk mengetahui granul effervescent ekstrak daun binahong yang diformulasikan telah memenuhi persyaratan dan menentukan formulasi granul effervescent yang terbaik. Penelitian ini merupakan penelitian deskriptif eksperimental dengan pengambilan data dari evaluasi granul effervescent. Untuk membuat sediaan granul effervescent terlebih dahulu dilakukan ekstraksi daun binahong. Ekstrak diperoleh dari metode maserasi menggunakan pelarut etanol 70%. Formula granul effervescent dibuat sebanyak tiga buah dengan variasi konsentrasi ekstrak F1 7,4%; F2 14,8%; dan F3 22,2%. Granul effervescent daun binahong dibuat dengan menggunakan metode granulasi basah dan dilakukan evaluasi mutu fisik granul meliputi uji organoleptik, kadar air, volume tuang, volume guncang, daya alir, waktu dispersi, dan pH. Hasil penelitian menunjukkan semua granul effervescent ekstrak daun binahong (Anredera cordifolia (Tenore) Steen.) telah memenuhi persyaratan granul yang baik. Dari ketiga formulasi, granul terbaik adalah F3, di mana memiliki nilai terbaik pada pengujian kadar air, uji volume guncang, daya alir, dan pH. Kata kunci : formulasi, evaluasi, granul effervescent, daun binahong ABSTRACT The purpose of this research are to find out whether the formulation of effervescent granules from binahong leaves extract has met the standards for effervescent granules and determine the best formulation of effervescent granules. This research is descriptive experimental with data collection from evaluation of effervescent granules. To be able to make effervescent granules, extraction of binahong leaves must be made first. The extracts resulted from a maseration method with 70% ethanol. The effervescent granules formulation were made by 3 design based on their concentration F1 7.4%; F2 14.8%; and F3 22.2%. Effervescent granules of binahong leaves extract are prepared by using wet granulation method. Several physical tests were carried out on the results of effervescent granules of binahong leaves, including organoleptic test, moisture content test, pour volume test, volume of shringkage test, flow capacity test, dispersion test, and pH. The test results showed that all the effervescent granules of binahong leaves (Anredera cordifolia (Tenore) Steen.) have met the standard requirements as good granules. The third formula became the best formulation, With the best value in moisture content test, volume of shringkage test, flow capacity test, and pH. Keywords: formulation, evaluation, effervescent granules, binahong leaves Penulis korespondesi: Prasojo Pribadi DIII Farmasi, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Magelang Jl. Mayjend Bambang Soegeng, Mertoyudan, Magelang Email: prasojopribadi1983@gmail.com