S92 25th European Congress of Psychiatry / European Psychiatry 41S (2017) S69–S105 O065 Interplay of gut microbiota, body mass index and depression scores in anorexia nervosa: Preliminary data S. Mörkl 1,* , S. Lackner 2 , G. Gorkiewicz 3 , K. Kashofer 3 , C. Blesl 1 , A. Tmava 1 , A. Oberascher 2 , S. Holasek 4 1 Medical University of Graz, Psychiatry, Graz, Austria 2 Medical University of Graz, Institute of Pathophysiology and Immunology, Graz, Austria 3 Medical University of Graz, Institute of Pathology, Graz, Austria 4 Medical University of Graz, Instiute of Pathophysiology and Immunology, Graz, Austria * Corresponding author. Introduction Anorexia nervosa (AN) is a lethal psychiatric disease with only narrow treatment possibilities. Recent study results point out, that gut microbiota might be a contributing factor in the devel- opment and persistence of AN through effects on the gut-brain-axis. Methods We used 16SRNA sequencing to characterize the com- position and diversity of the gut microbiota of 18 AN patients, 19 normal weight controls and 19 athletes matched by age using stool samples. The QIIME-pipeline was used to assess the sequencing result. All participants completed an activity-questionnaire (IPAQ) and inventories to measure depression (BDI, HAMD). Results Kruskal-Wallis test identified significant differences in alpha-diversity (Chao-1-estimator [P = 0.013], number of observed species [P = 0.027]) between groups. Spearman-Correlation revealed a significant correlation of number of observed species (r = 0.366, P = 0.006) Chao-1-estimator (r = 0.352, P = 0.008) and BMI (Fig. 1). Furthermore, a higher BMI was related to lower depression scores (r = 0.351, P < 0.001). Although there was a tendency of a negative correlation of BDI-scores and alpha-diversity (r = –0.180, P = 0.059), correlations with depression scores and IPAQ-scores did not reach significance level (Fig. 1). Conclusions Our preliminary data demonstrate correlations of alpha-diversity and BMI. Further studies are needed to provide further insights in AN gut microbiota and its influence factors. Fig. 1 Disclosure of interest The authors have not supplied their decla- ration of competing interest. http://dx.doi.org/10.1016/j.eurpsy.2017.01.287 O066 The different effect of childhood trauma on amygdala and hippocampus in patients with bipolar disorder and healthy controls D. Janiri 1 , P. De Rossi 1 , A. Simonetti 1 , G. Spalletta 2 , G. Sani 1,* 1 Sapienza University of Rome, NeSMOS, Rome, Italy 2 IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, Rome, Italy * Corresponding author. Introduction Childhood trauma (CT) is a relevant environmen- tal stressor for bipolar disorder (BP). Amygdala and hippocampus are key areas involved both in the pathophysiology of BP and in mediating the biological response to stress. Objectives Structural neuroimaging studies help clarifying neural correlates of the relationship between BP diagnosis and CT. Aims To verify the impact of CT on amygdala and hippocam- pus and hippocampal subfields volumes in BP patients and healthy control (HC). Methods We assessed 105 outpatients, diagnosed with BPI or BPII according to DSM-IV-TR criteria, and 113 HC subjects. History of CT was obtained using the childhood trauma questionnaire (CTQ). High-resolution magnetic resonance imaging was performed on all subjects and volumes of amygdala, hippocampus, nucleus accum- bens, caudate, pallidum, putamen, thalamus and hippocampal subfields were measured through FreeSurfer. Results All deep gray matter structures were smaller in BP than HC. CT modulated the impact of the diagnosis on bilateral amyg- dala and hippocampus, in particular on subiculum, presubiculum and cornu ammonis CA1. It was associated with bilateral decreased volumes in HC and increased volumes in patients with BP. Conclusions Childhood trauma impacts on the amygdala and hip- pocampus, brain areas involved in response to stress and emotion processing, and specifically on the hippocampal subfields most implicated in learning trough positive/negative reinforcement. Disclosure of interest The authors have not supplied their decla- ration of competing interest. http://dx.doi.org/10.1016/j.eurpsy.2017.01.288 O067 Prevalence of psychopathological features in intellectual diability: The Italian SPAID-G multicentric study D. Scuticchio 1,* , M.O. Bertelli 1 , G. Chiodelli 2 , R. Cavagnola 2 , F. Manna 3 1 CREA Research and Clinical Center–San Sebastiano Foundation, Misericordia di Firenze, Florence, Italy 2 Fondazione Istituto Ospedaliero di Sospiro Onlus, Fondazione Istituto Ospedaliero di Sospiro Onlus, Cremona, Italy 3 Istituto Opera Don Guanella, Istituto Opera Don Guanella, Roma, Italy * Corresponding author. Introduction Despite increasing awareness of high prevalence of psychiatric disorders in people with intellectual disability (ID), diagnostic tools are few and scarcely used in daily practice. SPAID-G (psychiatric instrument for the intellectually disabled adult-general version) is the first Italian for carrying out psychi- atric diagnostic orientations in adults with ID. It was designed to be easy and quick instrument for daily clinical practice. Objectives/Aims The present study was aimed at evaluating psy- chometric and psychodiagnostic characteristics of the SPAID-G and at supplying new data on the prevalence rate of psychiatric disor- ders in a multicentric Italian sample of people with ID living in different settings. Methods The SPAID-G was consecutively administered to more than 800 persons with ID attending residential, rehabilitative or