_____________________________________________________________________________________________________ *Corresponding author: E-mail: sneha144.kota@gmail.com; Journal of Pharmaceutical Research International 33(47B): 292-297, 2021; Article no.JPRI.75984 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Effect of Magnesium Sulphate Nebulization on the Incidence of Postoperative Sore Throat in Patients Requiring Endotracheal Intubation for General Anesthesia Vivek Chakole 1 , Kota Sneha 1* , Shilpa Shankar 1 and Sheetal Madavi 1 1 Jawaharlal Nehru Medical College, Sawangi, Wardha 442001, India. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i47B33127 Editor(s): (1) Dr. Ana Cláudia Coelho, University of Trás-os-Montes and Alto Douro, Portugal. Reviewers: (1) Sakshi, AIIMS Rishikesh, India. (2) Nihar Ranjan Tripathy, DHH Malkangiri, India. Complete Peer review History: https://www.sdiarticle4.com/review-history/75984 Received 22 August 2021 Accepted 27 October 2021 Published 02 November 2021 ABSTRACT Background: Post-operative sore throat (POST) is one of the most common anesthesia related complication. It is one of the undesirable post-operative events. Several Non pharmacological and pharmacological methods tried to reduce POST. we planned to study the efficacy of magnsesium sulphate nebulization in reduction of post operative sore throat. Study Design: Prospective, comparative observational study. Place and Duration of Study: Department of anesthesiology, AVBRH, from June 2020 to November 2020. Materials and Methods: observational study of 60 cases divided into two equal groups. Patients included in the study were of either gender belonging to American Society of Anesthesiologists (ASA) status 1 or 2 undergoing elective surgery of approximately 2 h or more duration requiring tracheal intubation. Patients in Group N were nebulized with 3 ml of normal saline and the patients in Group M were nebulized with 3 ml of 225 mg isotonic nebulized magnesium sulfate for 15 min. The incidence of POST at rest and on swallowing at 0, 2, 4,12 and 24 h in the postoperative period were evaluated. Short Research Article