 Corresponding author: Junaid Tantray; Email: Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0. A comprehensive review on comparative study of Ayurveda and allopath in management of psoriasis Ravi Kumar 1 , Shalini Saini 1 , Sumit Kumar Singh 1 , Akash Kumar 1 , Sumit Karanwal 1 , Ravi Shankar Dwivedi 1 , Aditya Pundir 1 , Tauheed Malik 1 , Rao Ubedulla 1 and Junaid Tantray 2 , * 1 Roorkee College of Pharmacy, Roorkee Uttarakhand, India. 2 NIMS Institute of Pharmacy, NIMS University Rajasthan Jaipur, Rajasthan, India. World Journal of Advanced Research and Reviews, 2023, 17(01), 615–624 Publication history: Received on 12 December 2022; revised on 20 January 2023; accepted on 22 January 2023 Article DOI: https://doi.org/10.30574/wjarr.2023.17.1.0108 Abstract A common skin disorder called psoriasis causes thickened patches of the skin. Typically, it is discovered to be covered with silvery scales. Although psoriasis is regarded as a skin condition, it is actually the outcome of an immune system dysfunction. Types of psoriasis-Plaque psoriasis (psoriasis vulgaris), Pustular psoriasis, Nail psoriasis, Guttate psoriasis, Flexural psoriasis, Erythrodermic psoriasis. Activated T cells go into the skin from the circulation and lymph nodes and release cytokines (INF, IL-2) that cause pathologic alterations. Other cytokines like TNF- and IL-8 are produced locally by neutrophils and keratinocytes. Keratinocyte proliferation is a result of T-cell generation and activation. Histocompatibility studies show relationships between histocompatibility antigens and HLA-C6, TNF, and IL-3.1)  T-helper ½,  Th17 & Th17 Cytokines,  Dendritic cells, IL-23 and TNF-α. They have many causes that help in develop the psoriasis are  Genetics,  Lifestyle,  HIV,  Microbes,  Medications. They have many treatment therapies are- Topical therapy-  Corticosteroids,  Calcipotriene,  Tazarotene. Keywords: Psoriasis; Keratinocyte; Cytokines; Pustular psoriasis; Allopathy; Guttate psoriasis