How to Cite: Saif, M. Y. S., Ismaeel, A. Y., Sayed, A. H., & Saeed, M. A. E. (2022). Impacts of smoking & ocular activity on Behcet disease & normal control by optical coherence tomography angiography (OCTA) in Upper Egypt. International Journal of Health Sciences, 6(S4), 2575–2593. https://doi.org/10.53730/ijhs.v6nS4.7564 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Manuscript submitted: 27 March 2022, Manuscript revised: 18 April 2022, Accepted for publication: 9 May 2022 2575 Impacts of smoking & ocular activity on Behcet disease & normal control by optical coherence tomography angiography (OCTA) in Upper Egypt Mohamed Yasser Sayed Saif OPhthalmology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt Email: weremoments@gmail.com Ahmed Yehia Ismaeel Medicine Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt Email: weremoments@gmail.com Amira Hamdi Sayed OPhthalmology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt Email: weremoments@gmail.com Mostafa Abd Elnabi Saeed OPhthalmology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt Email: weremoments@gmail.com Abstract---Retinal vasculitis and vein occlusions are common causes of serious visual loss in Behcet’s disease. The aim of the current work was the comparison of the OCTA results of BU cases, BD without uveitis cases &normal control was further subdivided to smokers &non-smokers to permit us to recognize retinal micro-circulation variations at the macular level in BU cases even in the nonattendance of preceding angiographic diagnosing of vasculitis & impact of smoking on BD clinical results of Behcet uveitis(BU), Behcet disease with no uveitis cases &normal control by the following parameters; Vessel density of macular area (VD) & foveal Avascular zone (FAZ) using OCTA. The conclusion of this study shows reduction of vessel density of macular area in Behcet uveitis (BU) rather than Behcet disease without uveitis &normal control & Enlarged FAZ in BU rather than BD without uveitis & normal control. The study results revealed areas of hypoperfusion of macular area even in BD without clinical signifacnce. Hazards of smoking on uveitis cases. There is a need to larger samples & lack of stable treatment protocols.