_____________________________________________________________________________________________________ *Corresponding author: E-mail: korsahjnr@gmail.com, skorsah@central.edu.gh; Asian J. Res. Infect. Dis., vol. 13, no. 2, pp. 26-33, 2023 Asian Journal of Research in Infectious Diseases Volume 13, Issue 2, Page 26-33, 2023; Article no.AJRID.99305 ISSN: 2582-3221 Outbreak of Cholera in Ghana: A Systematic Review from 2010 to 2020 John Antwi Apenteng a , Samuel Korsah a* , Miriam Tagoe a , Nathaniel Nene Nortey b , Jessica Korsah a , Benedicta Delase Wobetsey a and Frederick Akuffo Owusu c a Department of Pharmaceutical Sciences, School of Pharmacy, Central University, Accra, Ghana. b Institute of Traditional and Alternative Medicine (ITAM), University of Health and Allied Sciences, Ho, Ghana. c Department of Pharmaceutics, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/AJRID/2023/v13i2261 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/99305 Received: 01/03/2023 Accepted: 01/05/2023 Published: 08/05/2023 ABSTRACT Background: Cholera affects several hundred thousand individuals worldwide each year. According to estimates, more than 20 million individuals in Ghana are at danger of contracting the illness. However, research from Asia and other continents continues to be a major source of information for understanding cholera epidemiology in Africa, particularly in its coastal nations. The purpose of the study was to evaluate Ghana's cholera epidemics each year. Methods: A thorough analysis of articles that have been published on cholera outbreaks worldwide and in Ghana. A thorough search was done in the databases of Science Direct, PubMed, and Google Scholar to retrieve and to review research works published on cholera. Results: Findings suggest cholera has been a significant public health issue for Ghana every year since the first case was reported in 1970. Greater Accra is the area with the most cholera cases each year, with Accra being the district with the most cases. Greater Accra alone reported 58.5% of Systematic Review Article